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Sensitivity analysis of fed-batch fermentation for the production of penicillin G

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Biotechnology Techniques

Summary

The mixed metabolism model of Nicolaiet al. (1991) has been used to analyse the sensitivity of fed-batch fermentation for penicillin G with respect to four parameters. The cases of fully endogenous, fully maintenance and mixed metabolisms have been studied. Sensitivities with respect to two parameters,K x andK i, were much larger than for the other two. Differences between the three kinds of metabolism were sharpest forK p. The implications of both observations are discussed.

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Authors and Affiliations

  1. Institute of Microbial Technology, Sector 39-A, P.O. Box 1304, 160 014, Chandigarh, India

    P. R. Patnaik

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  1. P. R. Patnaik
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Patnaik, P.R. Sensitivity analysis of fed-batch fermentation for the production of penicillin G. Biotechnol Tech 6, 9–14 (1992). https://doi.org/10.1007/BF02438679

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  • DOI: https://doi.org/10.1007/BF02438679

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