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Mitochondrial components in the mechanism of antihypoxic effects of baikal scullcap extract

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Antioxidant properties of baikalin, a flavonoid from baikal scullcap (Scutellaria baikalensis Georgi), depend on its ability to scavenge free radicals. In contrast to standard antioxidant ionol (butylated hydroxytoluene) baikal scullcap extract and baikalin possess cerebroprotective activity and stabilize energy metabolism in rat brain during hypoxia. Pharmacological effect of the extract is determined by the presence of a falvonoid. It is suggested that antihypoxic effect of baikalin depends on its ability to interact with mitochondrial NADH dehydrogenase.

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Authors and Affiliations

  1. Laboratory of Molecular Pharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, USSR

    V. A. Khazanov & R. R. Saifutdinov

Authors
  1. V. A. Khazanov
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  2. R. R. Saifutdinov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 327–329, September 1999

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Khazanov, V.A., Saifutdinov, R.R. Mitochondrial components in the mechanism of antihypoxic effects of baikal scullcap extract. Bull Exp Biol Med 128, 942–944 (1999). https://doi.org/10.1007/BF02438092

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  • DOI: https://doi.org/10.1007/BF02438092

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