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Concentration-dependent inversion of antioxidant and prooxidant effects of β-carotene in tissuesin vivo

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Low doses (below 20 mg/kg) of oral β-carotene inhibit, while high doses (above 100 mg/kg) activate ascorbate-dependent LPO in rat liver and myocardial cells. Administration of β-carotene in a dose of 20 mg/kg decreased by 34% infarction zone in coronary occlusion, while the dose of 100 mg/kg was ineffective. Anin vivo concentration-dependent inversion of β-carotene from antioxidant to prooxidant in tissues is hypothesized. Pharmacological efficacy of β-carotene is determined by its antioxidant effect, while high doses provoke the prooxidant effect and can lead to negative consequences.

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Authors and Affiliations

  1. Laboratory of Biochemistry of Free-Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research and Production Complex, Ministry of Health of the Russian Federation, Moscow

    V. Z. Lankin, A. K. Tikhaze, G. G. Konovalova & A. I. Kozachenko

Authors
  1. V. Z. Lankin
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  2. A. K. Tikhaze
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  3. G. G. Konovalova
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  4. A. I. Kozachenko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 314–316, September, 1999

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Lankin, V.Z., Tikhaze, A.K., Konovalova, G.G. et al. Concentration-dependent inversion of antioxidant and prooxidant effects of β-carotene in tissuesin vivo . Bull Exp Biol Med 128, 930–932 (1999). https://doi.org/10.1007/BF02438088

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  • DOI: https://doi.org/10.1007/BF02438088

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