Bioglycans isolated from chaga in a concentration of 0.0001% reduced frequency of action potential in venous sinus cells of frog heart during the first 15–30 min of exposure, then this parameter increased by 10% per hour over 3.5 h, and was 41±3 min−1 from the 4th to the 20th hour of incubation. The frequency of action potentials in heart strips in the chaga extract was 40% higher than in Ringer's solution. The effect of chaga bioglycan is probably associated with adsorption on myocyte membranes. Binding of Ca2+ to bioglycans observed during the first 30 min inhibited efflux of intracellular Ca2+.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 264–266, September, 1999
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Golovko, V.A. Effects of bioglycans isolated from birch fungiinonotus obliquus on electric activity of venous sinus cells in frog heart. Bull Exp Biol Med 128, 888–889 (1999). https://doi.org/10.1007/BF02438075
- action potential