Effects of bioglycans isolated from birch fungiinonotus obliquus on electric activity of venous sinus cells in frog heart

Abstract

Bioglycans isolated from chaga in a concentration of 0.0001% reduced frequency of action potential in venous sinus cells of frog heart during the first 15–30 min of exposure, then this parameter increased by 10% per hour over 3.5 h, and was 41±3 min−1 from the 4th to the 20th hour of incubation. The frequency of action potentials in heart strips in the chaga extract was 40% higher than in Ringer's solution. The effect of chaga bioglycan is probably associated with adsorption on myocyte membranes. Binding of Ca2+ to bioglycans observed during the first 30 min inhibited efflux of intracellular Ca2+.

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References

  1. 1.

    V. A. Golovko,Fiziol. Zh. SSSR,72, No. 12, 933–939 (1986).

    PubMed  CAS  Google Scholar 

  2. 2.

    T. L. Desalen', O. V. Tsepaeva, N. A. Sosnina,et al., Byull. Eksp. Biol. Med.,123, No.1, 91–93 (1997).

    Article  Google Scholar 

  3. 3.

    R. G. Ovodova, V. V. Golovchenko, O. A. Bushneva,et al., Resin Industry and Organic Synthesis [in Russian], Syktyvkar (1996).

  4. 4.

    G. L. Ryzhova, S. S. Kravtsova, S. A. Matasova,et al., Khim. Farm. Zh.,31, No. 10, 44–47 (1997).

    CAS  Google Scholar 

  5. 5.

    D. L. Campbell, R. L. Rasmusson, and H. C. Strauss,Annu. Rev. Physiol.,54, 279–302 (1992).

    PubMed  CAS  Article  Google Scholar 

  6. 6.

    C. Garnier, M. A. V. Axelos, and J.-F. Thibaoult,Carbohydr. Res.,240, 219–232 (1993).

    CAS  Article  Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 264–266, September, 1999

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Golovko, V.A. Effects of bioglycans isolated from birch fungiinonotus obliquus on electric activity of venous sinus cells in frog heart. Bull Exp Biol Med 128, 888–889 (1999). https://doi.org/10.1007/BF02438075

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Key Words

  • chag
  • bioglycans
  • action potential
  • pacemaker