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Brain contents of substance P, diazepam-binding inhibitor, and neuropeptide Y in high- and low-anxiety inbred rats during stress

  • Physiology
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Abstract

The content of substance P in the hippocampus, hypothalamus, and midbrain of WAG/G rats surpassed these in Fischer-344 rats. After a 15-min stay in a shuttle box, the level of substance P in the hypothalamus and especially in the hippocampus decreased only in WAG/G rats. The content of diazepam-binding inhibitor in the hippocampus and midbrain of WAG/G rats was higher than in Ficher-344 rats. Stress increased the content of diazepam-binding inhibitor only in Fischer-344 rats. Midbrain content of neuropeptide Y in intact and stressed WAG/G rats was significantly lower than in Fischer-344 rats. There were no interstrain differences in the initial hypothalamic levels of neuropeptide Y between WAG/G and Fischer-344 rats. However, 15-min stress in the shuttle box increased hypothalamic content of neuropeptide Y only in Fischer-344 rats. Thus, high-anxiety rats are characterized by a low density of benzodiazepine receptors, decreased levels of substance P and diazepam-binding inhibitor, and high brain content of neuropeptide Y.

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Authors and Affiliations

  1. Laboratory of Attraction Neurobiology and Laboratory of Biochemistry, Institute of Drug Abuse, Russian Ministry of Health, Moscow

    S. K. Sudakov, N. N. Terebilina, O. F. Medvedeva, I. V. Rusakova & S. R. Goldberg

  2. Department of Preclinical Pharmacology, National Institute of Drug Abuse, American National Institute of Health, Baltimore

    S. K. Sudakov, N. N. Terebilina, O. F. Medvedeva, I. V. Rusakova & S. R. Goldberg

Authors
  1. S. K. Sudakov
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  2. N. N. Terebilina
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  3. O. F. Medvedeva
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  4. I. V. Rusakova
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  5. S. R. Goldberg
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 9, pp. 254–257, September, 1999

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Sudakov, S.K., Terebilina, N.N., Medvedeva, O.F. et al. Brain contents of substance P, diazepam-binding inhibitor, and neuropeptide Y in high- and low-anxiety inbred rats during stress. Bull Exp Biol Med 128, 879–881 (1999). https://doi.org/10.1007/BF02438072

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  • DOI: https://doi.org/10.1007/BF02438072

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