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Assignment of the human peroxisomal palmitoyl-CoA oxidase gene to chromosome 17q23-qter by PCR technique

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Journal of Inherited Metabolic Disease

Summary

Human peroxisomal palmitoyl-CoA oxidase plays a pivotal role in the β-oxidation of fatty acids. Its importance is reflected by the severity of the disease associated with its deficiency in man. The gene was previously mapped to chromosome 17q25 with a FISH technique and is now confirmed using a PCR technique.

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References

  • Aoyama T, Tsushima K, Souri M, et al (1994) Molecular cloning and functional expression of a human peroxisomal acyl-CoA oxidase.Biochem Biophys Res Commun 198: 1113–1118.

    Article  PubMed  CAS  Google Scholar 

  • Chu C, Mao LF, Schultz H (1994) Estimation of peroxisomal beta-oxidation in rat heart by a direct assay of acyl-CoA oxidase.Biochem J 302: 23–39.

    PubMed  CAS  Google Scholar 

  • Fournier B, Smeitink JAM, Dorland L, Berger R, Saudubray J-M, Poll-The BT (1994a) Peroxisomal disorders: a review.J Inher Metab Dis 17: 470–486.

    Article  PubMed  CAS  Google Scholar 

  • Fournier B, Saudubray J-M, Benichou B, et al (1994b) Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy.J Clin Invest 94: 526–531.

    Article  PubMed  CAS  Google Scholar 

  • Lazarow PB, de Duve C (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.Proc Natl Acad Sci USA 73: 2043–2046.

    Article  PubMed  CAS  Google Scholar 

  • Miyazawa S, Hayashi H, Hijikata M, et al (1987) Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase gene.J Biol Chem 262: 8131–8137.

    PubMed  CAS  Google Scholar 

  • Osmundsen H, Bremer J, Pedersen JI (1991) Metabolic aspects of peroxisomal β-oxidation.Biochim Biophys Acta 1085: 141–158.

    PubMed  CAS  Google Scholar 

  • Osumi T, Ishii N, Miyazawa S, Hashimoto T (1987) Isolation and structural characterization of rat acyl-CoA oxidase gene.J Biol Chem 262: 8138–8143.

    PubMed  CAS  Google Scholar 

  • Poll-The BT, Roels F, Ogier H, et al (1988) A new peroxisomal disorder with enlarged peroxisomes and specific deficiency of acyl-Coa oxidase (pseudo-neonatal adrenoleukodystrophy).Am J Hum Genet 42: 422–434.

    PubMed  CAS  Google Scholar 

  • Schepers L, Van Velhoven PP, Casteels M, Eyssen HJ, Mannaerts GP (1990) Presence of three acyl-CoA oxidases in rat liver peroxisomes: an inducible fatty acyl-CoA oxidase, a noninducible fatty acyl-CoA oxidase, and a noninducible trihydroxycoprostanoyl-CoA oxidase.J Biol Chem 265: 5242–5246.

    PubMed  CAS  Google Scholar 

  • Schram AW, Goldfischer S, Van Roermund CWT, et al (1981) Human peroxisomal 3-oxoacyl-CoA thiolase deficiency.Proc Natl Acad Sci USA 84: 2494–2496.

    Article  Google Scholar 

  • Suzuki Y, Shimozawa N, Yajima S, et al (1994) Novel subtype of peroxisomal acyl-CoA oxidase deficiency and bifunctional enzyme deficiency with detectable enzyme protein: identification by means of complementation analysis.Am J Hum Genet 54: 36–43.

    PubMed  CAS  Google Scholar 

  • Van Tuinen P, Rich DC, Summers KM, Ledbetter DH (1987) Regional mapping panel for human chromosome 17: application to neurofibromatosis type 1.Genomics 1: 374–381.

    Article  PubMed  Google Scholar 

  • Van Tuinen P, Dobyns WB, Rich DC, et al (1988) Molecular detection of microscopic and submicroscopic deletions associated with Miller-Dieker syndrome.Am J Hum Genet 43: 587–596.

    Google Scholar 

  • Van Veldhoven PP, Vanhove G, Vanhoutte F, et al (1991) Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase.J Biol Chem 266: 24676–24683.

    PubMed  Google Scholar 

  • Van Veldhoven PP, Vanhove G, Asselberghs S, Eyssen HJ, Mannaerts GP (1992) Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase.J Biol Chem 267: 20065–20074.

    PubMed  Google Scholar 

  • Vanhove GF, Van Veldhoven PP, Fransen M (1993) The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney.J Biol Chem 268: 10335–10344.

    PubMed  CAS  Google Scholar 

  • Varanasi U, Chu R, Chu S, et al (1994) Isolation of the human peroxisomal acyl-CoA oxidase gene: organisation, promoter analysis, and chromosomal localization.Proc Natl Acad Sci USA 91: 3107–3111.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Children's Medical Center of Dallas, 1935 Motor Street, 75235, Dallas, TX, USA

    N. N. Moghrabi, D. B. Dawson & M. J. Bennett

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  1. N. N. Moghrabi
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  2. D. B. Dawson
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  3. M. J. Bennett
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Moghrabi, N.N., Dawson, D.B. & Bennett, M.J. Assignment of the human peroxisomal palmitoyl-CoA oxidase gene to chromosome 17q23-qter by PCR technique. J Inherit Metab Dis 18, 705–709 (1995). https://doi.org/10.1007/BF02436760

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  • DOI: https://doi.org/10.1007/BF02436760

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