Skip to main content
SpringerLink
Log in

Age related accumulation of intranuclear membranous inclusions in female mice

  • Published:
AGE Aims and scope Submit manuscript

Abstract

The nuclei of cells from the supraoptic nucleus (SON) of virgin female C57BL/lcrfat mice, ranging from eight to thirty-two months of age, were studied by electron microscopy. A quantitative study has shown that the frequency of membranous and fibrillar inclusions within the cell nuclei increase with age, but the membranous inclusions decline at extreme age, (32 months). Inclusions of either type were rarely encountered in young or old male mice.

Cells containing these inclusions appear otherwise normal without degenerative changes. The membranous inclusions seem to lack organisation suggesting that they may be inert and functionless in the aging animal. The fibrillar inclusions, however, appear far more regular and organised.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Feldman, M. L., and Peters, A.: Intranuclear rods and sheets in rat cochlear nucleus. J. Neurocytol., 1: 109–127, 1972.

    Article  PubMed  CAS  Google Scholar 

  2. Davies, I. and Fotheringham, A. P.: The influence of age on the hypothalamo-neurohypophysial system of the mouse. A quantitative ultrastructural analysis of the supraoptic nucleus. Mech. Age. Dev., 12:93–105, 1980.

    Article  CAS  Google Scholar 

  3. Field, E. J., and Peat, A.: Intranuclear inclusions in neurones and glia: a study in the aging mouse. Gerontologia, 17: 129–138, 1971.

    Article  PubMed  CAS  Google Scholar 

  4. Wolfe, D. E.: The epiphyseal cell: an electron-microscopic study of its intercellular relationships and intracellular morphology in the pineal body of the albino rat. Progr. Brain Res., 10: 332–386, 1965.

    Article  CAS  Google Scholar 

  5. Johnson, J. E., Jr., & Miquel, J.: Fine structural changes in the lateral vestibular nucleus of aging rats. Mech. Age Dev., 3: 203–224, 1974.

    Article  Google Scholar 

  6. Nakayama, I., and Nickerson, P. A.: Intra-nuclear inclusions in mammotrophs of the female Mongolian gerbil. Amer. J. Anat., 135: 93–104, 1972.

    Article  PubMed  CAS  Google Scholar 

  7. Nickerson, P. A.: Induction of intranuclear inclusions by estrogen in mammotrophs of the Mongolian gerbil. J. Ultrastruct. Res., 44: 41–48, 1973.

    PubMed  CAS  Google Scholar 

  8. Nickerson, P. A.: Effect of partial thyroidectomy, propylthiouracil or thyroxine on estrogen-induced intranuclear inclusions in mammotrophy of the Mongolian gerbil. Tissue and Cell, 7: 663–772, 1975.

    Google Scholar 

  9. Dahl, E.: The fine structure of nuclear inclusions. J. Anat., 106: 255–262, 1970.

    PubMed  CAS  Google Scholar 

  10. Séite, R., and Mei, N.: Influence de la stimulation électrique sur la fréquence des bâtonnets intranucléaires des neurones sympathiques. Etude quantitative en microscopic é 1ectronique. C. R. Acad. Sci. Ser. D., 272: 3352–3355, 1971.

    Google Scholar 

  11. Tweedle, C. D., and Hatton, G. I.: Ultrastructural changes in rat hypothalamic neurosecretary cells and their associated gila during minimal dehydration and rehydration. Cell Tiss. Res. 181: 59–72, 1977.

    Article  CAS  Google Scholar 

  12. Kalimo, H.: Ultrastructural studies on the hypothalamic neurosecretory neurons of the rat. III. Paraventricular and supraoptic neurons during lactation and dehydration. Cell Tiss. Res., 163: 151–168, 1975.

    Article  CAS  Google Scholar 

  13. Rechardt, L.: Electron microscopic and histochemical observations on the supraoptic nucleus of normal and dehydrated rats. Acta physiol, scand., Suppl. 329: 1–79, 1969.

    CAS  Google Scholar 

  14. Morris, J. F. and Dyball, R. E. J.: A quantitative study of the ultrastructural changes in the hypothalamo-neurohypophysial system during and after experimentally induced hypersecretion. Cell Tiss. Res. 149: 525–535, 1974.

    Article  CAS  Google Scholar 

  15. Zambrano, D., and De Robertis, E.: The secretary cycle of supraoptic neurones in the rat. A structural-functional correlation. Z. Zellforsch, 73: 414–431, 1966.

    Article  PubMed  CAS  Google Scholar 

  16. Zambrano, D., and DeRobertis, E.: Ultrastructure of the hypothalamic neurosecretory system of the dog. Z. Zellforsch, 81: 264–282, 1967.

    Article  PubMed  CAS  Google Scholar 

  17. Popoff, N. and Stewart,: The fine structure of nuclear inclusions in the brain of experimental golden hamsters. J. Ultrastruct. Res., 23: 346–361, 1968.

    Article  Google Scholar 

  18. Séite, R., Escaig, J., and Couineau, S.: Microfilaments at microtubules nucléaires et organisation ultrastructurale des batonnets intranucléaires des neurones sympathiques. J. Ultrastruct. Res., 37: 449–478, 1971.

    Article  PubMed  Google Scholar 

  19. Seigel, S.: Nonparametric statistics for the behavioral sciences. Tokyo, McGraw-Hill Book Company, Inc., 1956, p. 116.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Geigy Unit for Research in Aging, University of Manchester, Nell Lane, Manchester, M20 8LR, UK

    Andrew P. Fotheringham & Ioan Davies

  2. Department of Geriatric Medicine, University Hospital of South Manchester, Nell Lane, Manchester, M20 8LR, UK

    Andrew P. Fotheringham & Ioan Davies

Authors
  1. Andrew P. Fotheringham
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ioan Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Fotheringham, A.P., Davies, I. Age related accumulation of intranuclear membranous inclusions in female mice. AGE 3, 1–5 (1980). https://doi.org/10.1007/BF02434998

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02434998

Keywords

Search

Navigation