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Alteration and intracellular regeneration of hepatocytes under the effect of hepatitis C virus

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In chronic virus hepatitis C, two types of structural changes dominate in hepatocytes: multivesicular lipid infiltration and cell involution degeneration characterized by reduction of all cytoplasmic organelles and light-optic phenomenon of cytoplasma depletion with preserved structure of the nuclear compartment. These changes can be considered as adaptive cell response to cytopathic influence of hepatitis C virus.

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References

  1. G. F. Lakin,Biometry [in Russian], Moscow (1980).

  2. G. I. Nepomnyashchikh,Vital Morphology of Large Bronchi in Chronic Lung Diseases [in Russian], Novosibirsk (1977).

  3. G. I. Nepomnyashchikh,Boundary Tissue (Mucosa and Skin) in the Morphogenesis of Pathological Processes [in Russian], Novosibirsk (1996).

  4. G. I. Nepomnyashchikh, L. M. Nepomnyashchikh, and Yu. G. Tsellarius,Regeneration and Plastic Insufficiency of Organs in Chronic Pathology [in Russian], Novosibirsk (1992).

  5. D. L. Nepomnyashchikh,Byull. Eksp. Biol. Med.,118, No. 9, 306–309 (1994).

    Google Scholar 

  6. D. L. Nepomnyashchikh,Chronic Hepatitis: Pathomorphology of the Liver and Stomach in Regeneration and Plastic Insufficiency, Abstract of Doct. Med. Sci. Dissertation. Novosibirsk (1998).

  7. L. M. Nepomnyashchikh, E. L. Lushnikova, L. V. Kolesnikova,et al., Morphometry and Stereological Analysis of the Myocardium: Tissue and Ultrastructure Organization [in Russian], Novosibirsk (1984).

  8. V. I. Pokrovskii,Ter. Arkh.,68, No. 11, 5–7 (1996).

    PubMed  CAS  Google Scholar 

  9. V. V. Serov,Ross. Zh. Gastroenterol. Gepatol. Koloproctol., No. 1, 36–40 (1996).

    Google Scholar 

  10. V. V. Serov and L. O. Severgina,Arkh. Patol.,58, No. 4, 61–64 (1996).

    PubMed  CAS  Google Scholar 

  11. H. J. G. Gundersen, T. F. Bendtsen, L. Korbo,et al., APMIS,96, 379–394 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. T. Kawamura, A. Furusaka, M. J. Koziel,et al., Hepatology, 25, No. 4, 1014–1421 (1997).

    Article  PubMed  CAS  Google Scholar 

  13. S. Sherlock,J. Hepatol.,23, No. 2, 3–7 (1995).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Ultrastructure Basis of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. I. Nepomnyashchikh, N. P. Tolokonskaya, L. M. Nepomnyashchikh, S. V. Aidagulova & G. A. Mezentseva

Authors
  1. G. I. Nepomnyashchikh
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  2. N. P. Tolokonskaya
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  3. L. M. Nepomnyashchikh
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  4. S. V. Aidagulova
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  5. G. A. Mezentseva
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 583–587, May, 1999

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Nepomnyashchikh, G.I., Tolokonskaya, N.P., Nepomnyashchikh, L.M. et al. Alteration and intracellular regeneration of hepatocytes under the effect of hepatitis C virus. Bull Exp Biol Med 127, 530–534 (1999). https://doi.org/10.1007/BF02434960

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  • DOI: https://doi.org/10.1007/BF02434960

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