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Catabolic effect of anabolic steroid in skeletal muscle under conditions of impaired neurotrophic regulation

  • Experimental Biology
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Abstract

Effect of anabolic steroid nandrolone (Phenobolin) on fast (plantar) and slow (soleus) skeletal muscles was studied in guinea pigs with impaired neurotrophic regulation (denervation, axonal transport blockade) or after tenotomy. Immunohistochemical analysis with monoclonal antibodies to fast myosin heavy chains showed that injection of anabolic steroid did not modify the relative content of fast and slow muscle fibers in the studied muscles under all experimental conditions. Injection of anabolic steroid did not modify the weight of the studied muscles and did not prevent its drop after denervation or tenotomy. Axonal transport blockade by colchicine application on the nerve induced the appearance of fast muscle fibers in the slow soleus muscle and an increase in its weight; in the slow muscle, nandrolone did not prevent the induction of fast myosin synthesis. Under conditions of axonal transport blockade, the agent exerted a catabolic effect and considerably reduced the muscle weight.

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Authors and Affiliations

  1. Department of Histology, Cytology, and Embryology, Kazan State Medical University, Kazan, USSR

    R. A. Dzamukov & V. V. Valiullin

Authors
  1. R. A. Dzamukov
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  2. V. V. Valiullin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol.127, No. 5, pp. 569–572, May, 1999

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Dzamukov, R.A., Valiullin, V.V. Catabolic effect of anabolic steroid in skeletal muscle under conditions of impaired neurotrophic regulation. Bull Exp Biol Med 127, 515–518 (1999). https://doi.org/10.1007/BF02434956

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  • DOI: https://doi.org/10.1007/BF02434956

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