Skip to main content
SpringerLink
Log in

Effects of water and ethanol extracts fromPaeonia lutea root bark on hemostatic parameters

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Anticoagulant and fibrinolytic activities, as well as inhibitory effect on platelet aggregation of water (2%) and ethanol extracts from the peony root bark (P. lutea) are demonstratedin vitro. Chronic peroral administration of the ethanol extract activates anticoagulant and fibrinolytic processes in rat blood. Water extract apart from anticoagulant activity, strongly enhanced blood fibrinolytic potency and inhibited platelet aggregation, which implies its possible antithrombotic properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. B. G. Volynskii, L. I. Bender, S. L. Fredman,et al., Plants in Medicine [in Russian], Saratov (1983).

  2. B. F. Kudryashov, L. A. Lyapina, and I. P. Baskova,Vestn. Mos. Univer. Ser. Biol., No. 5, 41–46 (1974).

    Google Scholar 

  3. L. A. Lyapina,Nov. Nauk. Tekh. Ser. Med. Hematol., No. 3, 2–6 (1997).

    Google Scholar 

  4. L. A. Lyapina, V. S. Novikov, V. E. Pastorova, et al.,Izv. Ros. Akad. Nauk Ser. Biol., No. 2, 249–251 (1995).

    Google Scholar 

  5. L. A. Lyapina, V. E. Pastorova, M. S. Uspenskaya, and V. S. Novikov,Vestn. Mos. Univer. Ser. Biol., No. 2, 28–31 (1995).

    Google Scholar 

  6. T. Astrup and S. Mullertz,Arch. Biochem. Biophys.,40, 346–351 (1952).

    Article  PubMed  CAS  Google Scholar 

  7. G. V. R. Born,Nature,194, 927–929 (1962).

    Article  PubMed  CAS  Google Scholar 

  8. K. Buluk, T. Januszko, and J. Olbromski,—Ibid.,191, 1093–1095 (1961).

    Article  CAS  Google Scholar 

  9. H. Ekimoto, G. Jrio, L. Araki, et al.,Planta Med.,57, No. 1, 56–60 (1991).

    PubMed  CAS  Google Scholar 

  10. E. Perlick, in:Gerinnungslaboratorium in Klinik and Praxis, Leipzig (1960), pp. 65–66.

Download references

Author information

Authors and Affiliations

  1. Laboratory of Blood Defense Systems, Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Lomonosov, USSR

    V. E. Pastorova, L. A. Lyapina, M. S. Uspenskaya & G. A. Ziadetdinova

Authors
  1. V. E. Pastorova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. Lyapina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. S. Uspenskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. A. Ziadetdinova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 533–535, May, 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pastorova, V.E., Lyapina, L.A., Uspenskaya, M.S. et al. Effects of water and ethanol extracts fromPaeonia lutea root bark on hemostatic parameters. Bull Exp Biol Med 127, 480–482 (1999). https://doi.org/10.1007/BF02434945

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02434945

Key words

Search

Navigation