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Effect of NO-synthase inhibitor L-NAME on occlusion and reperfusion arrhythmias in cats

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

On the model of occlusion/reperfusion arrhythmia in cats it was shown that repeated injections of the NO-synthase inhibitor L-NAME decreased the incidence of occlusion arrhythmias (to 40%), eliminated reperfusion-induced ventricular fibrillation, and drastically reduced the latency of occlusion arrhythmias. A single injection of L-NAME (20 mg/kg) immediately before ligation of the coronary artery did not decrease the incidence of occlusion and reperfusion arrhythmias.

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Authors and Affiliations

  1. Department of Faculty Therapy, Department of Cytology, Histology, and Embryology, N. P. Ogarev Mordovian State University, Saransk

    O. I. Kukushkina, L. K. Fedotkina, V. P. Balashov, L. A. Balykova & A. A. Sosunov

Authors
  1. O. I. Kukushkina
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  2. L. K. Fedotkina
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  3. V. P. Balashov
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  4. L. A. Balykova
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  5. A. A. Sosunov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 509–511, May, 1999

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Kukushkina, O.I., Fedotkina, L.K., Balashov, V.P. et al. Effect of NO-synthase inhibitor L-NAME on occlusion and reperfusion arrhythmias in cats. Bull Exp Biol Med 127, 460–462 (1999). https://doi.org/10.1007/BF02434938

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  • DOI: https://doi.org/10.1007/BF02434938

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