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Myocardial hypertropy in rabbits with renovascular hypertension under pharmacological blockade of angiotensin II synthesis and its interaction with specific receptors

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The dynamics of blood pressure, the weight of the heart and its subdivisions, and morphology of myocardium were studied in the rabbits with experimental renovascular hypertension. Treatment with inhibitors of angiotensin II synthesis (lotensin) or its interaction with specific receptors (valsartan) decreased blood pressure and the weight of the left ventricle, but did not affect the interrelations between structural elements in the heart, which remained the same as in hypertension-induced myocardial hypertrophy. In addition, these drugs impaired some parameters of cardiac activity attesting to myocardial overload, increase in collagen content in the myocardium, and decrease in the ratio of the numbers of capillaries and mitochondria to the weight of myofibrils.

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Authors and Affiliations

  1. Department of Pathological Physiology, University of Peoples' Friendship, Moscow

    V. A. Frolov, G. A. Drozdova, V. F. Mustyatsa, V. V. Balaev & P. Rieger

  2. Institute of Pathology, Heidelberg University, Heidelberg, Germany

    V. A. Frolov, G. A. Drozdova, V. F. Mustyatsa, V. V. Balaev & P. Rieger

Authors
  1. V. A. Frolov
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  2. G. A. Drozdova
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  3. V. F. Mustyatsa
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  4. V. V. Balaev
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  5. P. Rieger
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 506–509, May, 1999

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Frolov, V.A., Drozdova, G.A., Mustyatsa, V.F. et al. Myocardial hypertropy in rabbits with renovascular hypertension under pharmacological blockade of angiotensin II synthesis and its interaction with specific receptors. Bull Exp Biol Med 127, 457–459 (1999). https://doi.org/10.1007/BF02434937

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  • DOI: https://doi.org/10.1007/BF02434937

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