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Effects of acidic fibroblast growth factor on the development of experimental parkinsonism and striatal level of dopamine and its metabolites in mice of different ages

  • General Pathology and Pathological Physiology
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Abstract

Intranasal administration of acidic fibroblast growth factor suppressed the development of oligokinesia and muscular rigidity and elevated the content of dopamine and its metabolites (dihydroxyphenylacetic acid and homovanillic acid) in the striatum of 7-month-old mice with MPTP-induced Parkinsonian syndrome. In 14-month-old mice the antiparkinsonic effect of acidic fibroblast growth factor was weakened or absent. It is suggested that this factor is able to attenuate or postpone degeneration and death of nigral dopaminergic neurons.

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Authors and Affiliations

  1. Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    V. G. Kucheryanu, G. N. Kryzhanovskii, V. S. Kudrin, V. V. Yurasov, E. V. Nikushkin & I. V. Zhigal'tsev

Authors
  1. V. G. Kucheryanu
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  2. G. N. Kryzhanovskii
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  3. V. S. Kudrin
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  4. V. V. Yurasov
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  5. E. V. Nikushkin
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  6. I. V. Zhigal'tsev
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 502–505, May, 1999

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Kucheryanu, V.G., Kryzhanovskii, G.N., Kudrin, V.S. et al. Effects of acidic fibroblast growth factor on the development of experimental parkinsonism and striatal level of dopamine and its metabolites in mice of different ages. Bull Exp Biol Med 127, 454–456 (1999). https://doi.org/10.1007/BF02434936

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  • DOI: https://doi.org/10.1007/BF02434936

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