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Effect of Polyosm on viscoelastic properties of the craniospinal system in the model of acute hypertensive encephalopathy

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of Polyosm (polyethylene oxide 400 solution) on viscoelastic properties of the craniospinal system in cats and parameters of systemic hemodynamics were studied on the model of acute hypertensive encephalopathy, induced by intravenous injection of norepinephrine hydrotartrate and intracarotid infusion of papaverine hydrochloride. In control series, a sustained increase in the central venous and intracranial pressure, enhancement of resistance to liquor drainage, and pronounced increase in rigidity of the craniospinal system were observed. Intravenous infusion of Polyosm moderated these disturbances of the blood and liquor dynamics and restored viscoelastic properties of the craniospinal system to an almost initial level.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    M. B. Plotnikov, V. I. Smol'yakova & G. A. Chernysheva

  2. Siberian Medical University, Tomsk

    A. D. Avdoshin

Authors
  1. M. B. Plotnikov
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  2. V. I. Smol'yakova
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  3. G. A. Chernysheva
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  4. A. D. Avdoshin
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 499–502, May, 1999

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Plotnikov, M.B., Smol'yakova, V.I., Chernysheva, G.A. et al. Effect of Polyosm on viscoelastic properties of the craniospinal system in the model of acute hypertensive encephalopathy. Bull Exp Biol Med 127, 451–453 (1999). https://doi.org/10.1007/BF02434935

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  • DOI: https://doi.org/10.1007/BF02434935

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