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Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 6, pp 527–529 | Cite as

Dynorphin administered to Newborn rats modulates morphogenesis of the heart

  • N. P. Mel'nikova
  • S. S. Timoshin
  • V. I. Tsygankov
  • N. B. Murzina
  • G. G. Obukhova
  • Zh. D. Bespalov
General Pathology and Pathological Physiology

Abstract

Proliferation, activity of the nucleolar organizer region, and protein content in cardiomyocytes were studied in 21-day-old rats intraperitoneally treated with κ-opioid receptor agonist dynorphin A1–13 in a dose of 100 μg/kg on postnatal days 2–6. The content of catecholamines in the heart and proliferative activity of cardiomyocytes remained unaffected, but the number of nucleoli in cardiomyocyte nuclei and the integral optical density of cardiomyocytes stained with amido black B (protein content) increased. The data suggest that administration of dynorphin to newborn rats considerably modulates morphogenesis of the heart at later terms.

Key Words

myocardium cardiomyocytes protein synthesis nucleolar organizer region 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • N. P. Mel'nikova
    • 1
  • S. S. Timoshin
    • 1
  • V. I. Tsygankov
    • 1
  • N. B. Murzina
    • 1
  • G. G. Obukhova
    • 1
  • Zh. D. Bespalov
    • 1
  1. 1.Central Research LaboratoryFar Eastern State Medical UniversityKhabarovsk

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