AGE

, Volume 14, Issue 2, pp 33–38 | Cite as

Serum lipids and lipid peroxidation pattern in industrial and rural workers in India

  • K. K. Reddy
  • G. Bulliyya
  • T. Rama Chandraiah
  • K. S. Kumari
  • P. Reddanna
  • K. Thyagaraju
Article

Abstract

In order to study the impact of industrial pollutants or toxicants in free radical generation and age-associated cardiovascular diseases, serum cholesterol, high density lipoprotein (HDL)-cholesterol, lipid peroxide levels, uric acid and blood pressure were studied in 67 male urban industrial and 85 male rural workers. In industrial workers, the higher levels of cholesterol, lipid peroxides and uric acid are observed due to pollutants like smoke, tar or high furnace temperature. The incidence of hypertension is greater in industrial workers as compared to rural workers. Rural workers have higher levels of HDL-cholesterol. The elevated serum uric acid levels are thought to be a physiological compensatory mechanism against oxidative stress. The aim of the present study is to determine the difference between rural and industrial workers in relation to lipids and lipid peroxide levels. These results may demonstrate the important role of lipid peroxides in age-associated cardiovascular diseases.

Keywords

Cholesterol Lipid Peroxide Uric Acid High Density Lipoprotein Serum Cholesterol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Glavind, J., Hartmann, S., Clemmensen, J., Jensen, K.E., and Dam, H.: Studies on the role of lipoperoxides in human pathology. II. The presence of peroxidized lipids in the atherosclerotic aorta. Acta. Pathol., 30: 1–6, 1952.Google Scholar
  2. 2.
    Dormandy, J.A., Hoare, E., Colley, J., Arrowsmith, D.E., and Dormandy, T.L.: Clinical haemodynamic rheological and biochemical findings in 126 patients with intermittent claudication. Br. Med. J., 8: 576–583, 1973.CrossRefGoogle Scholar
  3. 3.
    Fridovich, I.: The biology of oxygen radicals. Science, 201: 875–880, 1978.PubMedGoogle Scholar
  4. 4.
    Lloyd, G.G.: In Recent Advances in Clinical Psychiatry, edited by Grossmann, K.G., Churchill Livingstone, 1985, pp. 63–85.Google Scholar
  5. 5.
    Udupa, K.N.: In Stress and Its Management by Yoga, edited by Prasad, R.C., Motilal Banarsidas, 1985, p. 116.Google Scholar
  6. 6.
    Pryor, W.A.: Free radicals in biology. Academic Press, New York, 1981, vols. 1–5.Google Scholar
  7. 7.
    deDuve, C., and Hayaishi, O.: Tocopherol, Oxygen and Biomembranes. New York, Elsevier/North Holland, 1978.Google Scholar
  8. 8.
    Klebanoff, S.J.: Oxygen metabolism and the toxic properties of phagocytes. Ann. Intern. Med., 93: 480–489, 1980.PubMedGoogle Scholar
  9. 9.
    Flohe, L., Gunzies, W.A., and Ladenstein, R.: Glutathione Peroxidase, in Arias, I.M., Jakoby, W.B. (eds.), Glutathione, Metabolism and Function. New York, Raven Press, 1976, pp. 115–138.Google Scholar
  10. 10.
    Michaelson, A.M., McCord, J.M., and Fridovich, I. (eds.): Superoxide and Superoxide Dismutases. New York, Academic Press, 1977.Google Scholar
  11. 11.
    Ames, B.N., Cathcart, R., Schwiers, E., and Hochstein, P.: Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: A hypothesis. Proc. Natl. Acad. Sci. USA, 78: 6858–6262, 1981.PubMedGoogle Scholar
  12. 12.
    Turpeinen, O., Miettinen, M., Karvonen, M.J., Rione, P., Pekkarinnen, M., Lehtosuo, E.J., and Alivitra, P.: Diatetische Pravention Von herzgefasserkran Kungen, in Fettstoffwechselstorungen, edited by Schettler, G., Georg thime Verlag, Stuttgart, 1971, pp. 125–150.Google Scholar
  13. 13.
    Schilling, F.L., Christakis, G., Orbach, A., and Becker, W.H.: Serum cholesterol and triglyceride. An epidemiological and pathogenic interpretation. Am. J. Clin. Nutr., 22: 133–138, 1969.PubMedGoogle Scholar
  14. 14.
    Ringrose, H., and Zimmet, P.: Nutrient intakes in an urbanized micronesian population with a high diabetes prevalence. Am. J. Clin. Nutr., 32: 1334–1341, 1979.PubMedGoogle Scholar
  15. 15.
    Rose, G.A., Blackburn, H.G., Gillum, R.F., and Princeas, R.J.: Cardiovascular survey methods. MS No. 56, 2nd Edition, 1982.Google Scholar
  16. 16.
    Abell, L.L., Levy, B.B., Brodie, B.B., and Kendall, F.F.: A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J. Biol. Chem., 195: 357–366, 1952.Google Scholar
  17. 17.
    Lopes-Virella, M.F., Stone, P., Ellis, S., and Colwell, J.A.: Cholesterol determination in high density lipoproteins separated by three different methods. Clin. Chem., 23: 882–884, 1977.PubMedGoogle Scholar
  18. 18.
    Kei Satoh: Serum lipid peroxides in cerebrovascular disorders. Determined by a new calorimetric method. Clin. Chim. Acta, 90: 37–43, 1978.PubMedCrossRefGoogle Scholar
  19. 19.
    Natelson, S., and Kaser, M.: Uric acid, in Standard Methods of Clinical Chemistry, edited by Reiner, M., Academic Press, New York, 1953, vol. 1, pp. 123–135.Google Scholar
  20. 20.
    Kaplan, N.M.: Clinical Hypertension, 2nd edition. Baltimore, Williams and Wilkins, 1978, p. 7.Google Scholar
  21. 21.
    Sambasiva Rao, R.: Blood pressure in relation to age and sex in a rural population. Man in India, 59: 97–105, 1979.Google Scholar
  22. 22.
    Pongpaew, P., Saovakontha, S., Schelp, F.-P., Supawan, V., Hongtong, K., and Boonperm, P.: Serum lipid pattern in urban and rural Thai populations. J. Nutr. Sci. Vitaminol., 24: 289–296, 1978.PubMedGoogle Scholar
  23. 23.
    Davison, S., Passmore, R., Brock, J.F., and Trushwell, A.S.: Human Nutrition and Dietetics, 6th edition. Churchill Livingstone, London, 1975, pp. 380–392.Google Scholar
  24. 24.
    Narula, J., and Wasir, H.S.: High density lipoprotein cholesterol and antiatherogenic metabolism. Ind. Heart, J., 37: 323–325, 1985.Google Scholar
  25. 25.
    Fredrickson, D.S., Levy, R.I., and Lees, R.S.: Fat transport in lipoproteins: An integrated approach to mechanisms and disorders. New Engl. J. Med., 296: 34, 94, 148, 215, 273, 1967.CrossRefGoogle Scholar
  26. 26.
    Suematsu, T., Kamada, T., Abe, H., Kikuchi, S., and Yagi, K.: Serum lipoperoxide level in patients suffering from liver diseases. Clin. Chim. Acta, 79: 267–270, 1977.PubMedCrossRefGoogle Scholar
  27. 27.
    Emmerson, B.T.: In Uric Acid, Handbook of Experimental Pharmacology, edited by Kelly, W.N. and Weiner, I.M., Springer, New York, 1978, vol. 51, pp. 287–324.Google Scholar
  28. 28.
    Sato, Y., Hotta, N., Sakamoto, N., Matsuoka, S., Ohishi, N., and Yagi, K.: Lipid peroxide level in plasma of diabetic patients. Biochem. Med., 21: 104–107, 1979.PubMedCrossRefGoogle Scholar
  29. 29.
    Yagi, K., Matsuoka, S., Linnane, A.W., and Zimmet, P.: Plasma lipid peroxide levels in an urbanized micronesian population — Nauru. J. Nutr. Sci. Vitaminol., 27: 425–428, 1981.PubMedGoogle Scholar
  30. 30.
    Chio, K.S., Reiss, V., Fletcher, B., and Tappel, A.J.: Peroxidation of subcellular organelles: Formation of lipofuscin like fluorescent pigments. Science, 166:1535–1536, 1969.PubMedGoogle Scholar
  31. 31.
    Silver, M.J., Hoch, W., Koesis, J.J., Ingermann, C.M., and Smith, J.B.: Arachidonic acid causes sudden death in rabbits. Science, 183:1085–1087, 1974.PubMedGoogle Scholar

Copyright information

© American Aging Association, Inc. 1991

Authors and Affiliations

  • K. K. Reddy
    • 1
  • G. Bulliyya
    • 1
  • T. Rama Chandraiah
    • 1
  • K. S. Kumari
    • 2
  • P. Reddanna
    • 3
  • K. Thyagaraju
    • 4
  1. 1.Department of Physical AnthropologySri Venkateswara UniversityTirupatiIndia
  2. 2.S.V. Medical CollegeTirupatiIndia
  3. 3.Department of ZoologyS.V. UniversityTirupatiIndia
  4. 4.Department of BiochemistryS.V. UniversityTirupatiIndia

Personalised recommendations