Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 6, pp 1235–1238 | Cite as

Effects of sex steroid hormones on lipid peroxidation and glutathione antioxidant system in rat skin

  • P. V. Sergeev
  • T. V. Ukhina
  • N. L. Shimanovskii
Pharmacology and Toxicology


Effects of estradiol and testosterone on the intensity of lipid peroxidation and contents of glutathione redox system components in the dermis and epidermis of rat skin were studied. Only estradiol induced considerable dose-dependent and tissue-specific biphasic antioxidant effects on the skin.

Key words

skin dermis epidermis estradiol lipid peroxidation chemiluminescence glutathione 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • T. V. Ukhina
    • 1
  • N. L. Shimanovskii
    • 1
  1. 1.Department of Molecular Pharmacology and Radiobiology, Medicobiological FacultyRussian State Medical UniversityMoscow

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