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Effects of glucocorticoids and high density lipoproteins on activity of hepatocyte nuclei

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Combined exposure to high-density lipoproteins and glucocorticoids caused changes in the nucleus of rat hepatocytes. These changes most rapidly (within 10 min) appeared after stimulation of sinusoid cells and manifested themselves in enlargement of nucleoli, loosening of the fibrillar and accumulation of the granular components, and in an increase in nuclear membrane pore density. The increased binding and acridine orange enhanced red fluorescence attested to chromatin activation and enhanced gene expression. Resident macrophages play a key role in the realization of this mechanism.

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Authors and Affiliations

  1. Institute of Biochemistry, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk

    L. E. Panin, V. F. Maksimov & I. M. Korostyshevskaya

Authors
  1. L. E. Panin
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  2. V. F. Maksimov
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  3. I. M. Korostyshevskaya
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 650–653, December, 1999.

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Panin, L.E., Maksimov, V.F. & Korostyshevskaya, I.M. Effects of glucocorticoids and high density lipoproteins on activity of hepatocyte nuclei. Bull Exp Biol Med 128, 1223–1225 (1999). https://doi.org/10.1007/BF02434823

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  • DOI: https://doi.org/10.1007/BF02434823

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