Abstract
β-Adrenoceptor density in rat cerebral cortex 3-fold increased with the decrease in norepinephrine content over the first week of life. Intracerebral injection of 6-hydroxydopamine to 2-day-old rats decreased the content of norepinephrine and increased the density of β-adrenoceptors in the cerebral cortex measured on the 5th day of life. The data suggest that norepinephrine down-regulates cerebral β-adrenoceptors from the early stages of development of the neurochemical system.
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Translated fromByulleten' Eksperimental'noi Biologii i meditsiny, Vol. 128, No. 12, pp. 616–618, December, 1999
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Mel'nikova, L.B., Yushkova, A.A., Kalinina, T.S. et al. Interrelation between β-adrenoceptor density and norepinephrine content in the cerebral cortex of neonatal rats. Bull Exp Biol Med 128, 1193–1195 (1999). https://doi.org/10.1007/BF02434814
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DOI: https://doi.org/10.1007/BF02434814