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Interrelation between β-adrenoceptor density and norepinephrine content in the cerebral cortex of neonatal rats

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

β-Adrenoceptor density in rat cerebral cortex 3-fold increased with the decrease in norepinephrine content over the first week of life. Intracerebral injection of 6-hydroxydopamine to 2-day-old rats decreased the content of norepinephrine and increased the density of β-adrenoceptors in the cerebral cortex measured on the 5th day of life. The data suggest that norepinephrine down-regulates cerebral β-adrenoceptors from the early stages of development of the neurochemical system.

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Authors and Affiliations

  1. Laboratory of Genetic Bases of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk

    L. B. Mel'nikova, A. A. Yushkova, T. S. Kalinina, N. Yu. Surnina & N. N. Dygalo

Authors
  1. L. B. Mel'nikova
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  2. A. A. Yushkova
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  3. T. S. Kalinina
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  4. N. Yu. Surnina
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  5. N. N. Dygalo
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Translated fromByulleten' Eksperimental'noi Biologii i meditsiny, Vol. 128, No. 12, pp. 616–618, December, 1999

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Mel'nikova, L.B., Yushkova, A.A., Kalinina, T.S. et al. Interrelation between β-adrenoceptor density and norepinephrine content in the cerebral cortex of neonatal rats. Bull Exp Biol Med 128, 1193–1195 (1999). https://doi.org/10.1007/BF02434814

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  • DOI: https://doi.org/10.1007/BF02434814

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