Abstract
Repeated bilateral microinjections of bicuculline (5 μg), an antagonist of A-type GABA-receptors into the rostral and caudal neostriatum and globus pallidus impair realization of avoidance conditioned behavior in rats, but produce no motor disturbances (hyperkineses) similar to those produced by intrastriatal injection of picrotoxin. The most pronounced albeit compensated disturbances in avoidance behavior were found after blockade of the GABAergic system in the rostral neostriatum. In rats subjected to similar blockage in the globus pallidus the disturbances persisted after termination of bicuculline microinjections.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 613–615, December, 1999
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Yakimovskii, A.F. Effect of repeated microinjections of bicuculline into rostral and caudal neostriatum and globus pallidus on avoidance reaction in rats. Bull Exp Biol Med 128, 1190–1192 (1999). https://doi.org/10.1007/BF02434813
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DOI: https://doi.org/10.1007/BF02434813