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Effects of 25-hydroxycholesterol and progesterone on viscosity, cholesterol esterification, and protein-lipid interactions in macrophage membranes

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

25-Hydroxycholesterol stimulates and progesterone inhibits cholesterol esterification in mouse peritoneal macrophages in a dose-dependent manner. Fluorescence assay showed nonlinear changes in lipid viscosity and protein-lipid interactions in macrophage membranes under the effect of various doses of 25-hydroxycholesterol and progesterone, therefore opposite effects of studied steroids on acyl-CoA:cholesterol acyltransferase activity were not necessarily related to these factors.

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References

  1. G. E. Dobretsov,Fluorescence Probes in Studies of Cells, Membranes, and Lipoproteins [in Russian], Moscow (1989).

  2. A. V. Dolgov, M. I. Dushkin, and E. V. Mandrikova,Vopr. Med. Khim.,36, No. 4, 38–41 (1990).

    PubMed  CAS  Google Scholar 

  3. M. I. Dushkin, E. V. Mandrikova, G. Yu. Lyubimov,et al., Biokhimiya,55, No. 9, 1607–1615 (1990).

    CAS  Google Scholar 

  4. M. I. Dushkin, E. V. Mandrikova, and A. V. Dolgov,Vopr. Med. Khim.,37, No. 3, 2–5 (1991).

    PubMed  CAS  Google Scholar 

  5. C. Bhuvaneswaran, S. Synourivrettakou, and K. A. Mitropoulos,Biochem. Pharmacol.,53, No. 1, 27–34 (1997).

    Article  PubMed  CAS  Google Scholar 

  6. M. S. Brown and J. L. Goldstein,Ann. Rev. Biochem.,52, 223–261 (1983).

    Article  PubMed  CAS  Google Scholar 

  7. K. Clare, S. J. Hardwick, K. L. H. Carpenter,et al., Atherosclerosis,118, 67–75 (1995).

    Article  PubMed  CAS  Google Scholar 

  8. G. Deliconstantinos,Ciba Found. Symp.,153 190–199 (1990).

    PubMed  CAS  Google Scholar 

  9. F. Guardiola, R. Codony, P. B. Addis,et al., FD Chem. Toxic.,34, No. 2, 93–211 (1996).

    Google Scholar 

  10. K. E. Suckling and E. F. Stange,J. Lipid Res.,26, 647–671 (1985).

    PubMed  CAS  Google Scholar 

  11. J. Tabas and G. C. Boykow,J. Biol. Chem.,262, 12175–12181 (1987).

    PubMed  CAS  Google Scholar 

  12. J. Tabas,Curr. Opin. Lipid.,6, 260–268 (1995).

    Article  CAS  Google Scholar 

  13. H. Wang, P. Benfield, S. J. Germain,et al., Circulation,90, 341–351 (1994).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    M. I. Dushkin

  2. Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    N. G. Kolosova

  3. Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    A. F. Safina

Authors
  1. M. I. Dushkin
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  2. N. G. Kolosova
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  3. A. F. Safina
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2, pp. 145–148, February, 2000

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Dushkin, M.I., Kolosova, N.G. & Safina, A.F. Effects of 25-hydroxycholesterol and progesterone on viscosity, cholesterol esterification, and protein-lipid interactions in macrophage membranes. Bull Exp Biol Med 129, 124–127 (2000). https://doi.org/10.1007/BF02434787

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  • DOI: https://doi.org/10.1007/BF02434787

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