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Effect of trimetazidine on cerebral metabolism during acute ischemia complicated by hypoxia

  • General Pathology and Pathological Physiology
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Abstract

In experiments on rats, trimetazidine (25 mg/kg) prevented disturbances in energy metabolism and LPO activation in the brain under conditions of acute ischemia aggravated by hypoxia.

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References

  1. A. M. Alekseeva,Biokhimiya,16, No. 2, 97–103 (1951).

    CAS  Google Scholar 

  2. S. F. Barsukov, E. I. Dedov, G. I. Antonov,et al., Antihypoxants and Actoprotectors: Results and Perspectives [in Russian], Issue 2, St. Petersburg (1994).

  3. M. V. Bilenko,Ischemic and Reperfusion Damage to Organs (Molecular Mechanisms, Prevention, and Treatment) [in Russian], Moscow (1989).

  4. I. V. Zarubina and B. I. Krivoruchko,Ukr. Biokhim. Zh.,54, No. 4, 437–439 (1982).

    PubMed  CAS  Google Scholar 

  5. V. A. Zinchenko, in:Cytochrome C and Its Clinical Application [in Russian], Leningrad (1990), pp. 39–46.

  6. J. E. Cottrell,Anest. Reanimatol. No. 2, 81–85 (1996).

    Google Scholar 

  7. Methods of Biochemical Studies, Ed. M. I. Prokhorova [in Russian], Leningrad (1982).

  8. Myocardial Cytoprotection: From Stenocardia to Thrombolysis, Ed. M. E. Bertran [in Russian], Moscow (1995).

  9. A. V. Smirnov, I. V. Zarubina, and B. I. Krivoruchko,Eksp. Klin. Farmakol.,59, No. 5, 56–58 (1996).

    PubMed  CAS  Google Scholar 

  10. Z. A. Suslina and L. A. Geraskina,Klin. Farmakol. Ter.,5, No. 4, 80–82 (1996).

    Google Scholar 

  11. K. S. Ternovoi, Yu. P. Butylin, and Yu. I. Bobylev,Urgent States: Pathophysiology, Clinics, and Treatment [in Russian], Kiev (1984).

  12. E. S. Flamm, M. L. Seligman, and H. B. Demopoulos, in:Anesthesia and Neurosurgery, Eds. J. E. Cottrell and H. Turndorf, St. Louis (1980), pp. 248–266.

  13. C. Harpey, P. Clauser, C. Labrid,et al., Cardiovasc. Drug Rev.,6, No. 4, 292–312 (1989).

    Article  Google Scholar 

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2 pp. 142–144, February, 2000

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Smirnov, A.V., Zarubina, I.V., Krivoruchko, B.I. et al. Effect of trimetazidine on cerebral metabolism during acute ischemia complicated by hypoxia. Bull Exp Biol Med 129, 121–123 (2000). https://doi.org/10.1007/BF02434786

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  • DOI: https://doi.org/10.1007/BF02434786

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