Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 3, pp 250–252 | Cite as

Effect of endothelin-1 on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats

  • O. A. Lebed'ko
  • S. S. Timoshin
Biophysics and Biochemistry


Repeated (5-fold) intraperitoneal injections of 5×10−9 mol/kg endothelin-1 inhibited DNA synthesis in tracheal epitheliocytes and activated lipid peroxidation in the lungs of newborn rats. Endothelin-1 in a dose of 5×10−8 mol/kg stimulated proliferative activity of tracheal smooth muscle cells and intensified lipid peroxidation in the blood, which aggravated observed changes.

Key Words

endothelin DNA synthesis epithelium smooth muscle cells trachea 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • O. A. Lebed'ko
    • 1
    • 2
  • S. S. Timoshin
    • 1
    • 2
  1. 1.Siberian Division of the Russian Academy of Medical SciencesInstitute of Maternity and Child WelfareKhabarovsk
  2. 2.Far-Eastern State Medical UniversityKhabarovsk

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