Bulletin of Experimental Biology and Medicine

, Volume 129, Issue 3, pp 250–252 | Cite as

Effect of endothelin-1 on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats

  • O. A. Lebed'ko
  • S. S. Timoshin
Biophysics and Biochemistry
  • 19 Downloads

Abstract

Repeated (5-fold) intraperitoneal injections of 5×10−9 mol/kg endothelin-1 inhibited DNA synthesis in tracheal epitheliocytes and activated lipid peroxidation in the lungs of newborn rats. Endothelin-1 in a dose of 5×10−8 mol/kg stimulated proliferative activity of tracheal smooth muscle cells and intensified lipid peroxidation in the blood, which aggravated observed changes.

Key Words

endothelin DNA synthesis epithelium smooth muscle cells trachea 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    V. B. Gavrilov and N. I. Mishkorudnaya,Lab. Delo, No. 3, 33–36 (1983).Google Scholar
  2. 2.
    M. V. Kuskov, L. V. Kapilevich, M. B. Baskakov, and M. A. Medvedev,Byull. Eksp. Biol. Med.,126, No. 12, 625–627 (1998).Google Scholar
  3. 3.
    V. A. Nevzorova,NO-ergic Mechanisms of Regulation of Bronchi and Their Role in the Pathogenesis of Bronchial Asthma and Chronic Bronchitis, Abstract of Doct. Med. Sci. Dissertation, Vladivostok (1997).Google Scholar
  4. 4.
    N. V. Syromyatnikova, V. A. Goncharova, and T. V. Kotenko,Metabolic Activity of the Lungs [in Russian], Leningrad (1987).Google Scholar
  5. 5.
    T. N. Fedorova, T. S. Korshunova, and S. G. Larskii,Lab. Delo, No. 3, 25–27 (1983).Google Scholar
  6. 6.
    P. Carratu, M. Scuri, J. L. Styblo,et al., Am. J. Physiol.,272, No. 5, Pt. 1, L1021-L1024 (1997).PubMedGoogle Scholar
  7. 7.
    B. A. Freeman, H. Gutierrez, and H. Rubbo,Ibid.,268, No. 5, Pt. 1, L697-L698 (1995).PubMedGoogle Scholar
  8. 8.
    L. D. Hansen and W. T. Wariorick,Am. J. Clin. Pathol.,46, 117 (1966).Google Scholar
  9. 9.
    T. Kojima, Y. Isozaki-Fukuda, M. Takedatsu,et al., Eur. J. Pediatr.,151, No. 12, 913–915 (1992).PubMedCrossRefGoogle Scholar
  10. 10.
    P. Kumar, N. J. Kazzi, and S. Shankaran,Am. J. Perinatol.,13, No. 6, 335–341 (1996).PubMedGoogle Scholar
  11. 11.
    C. G. Murlas, A. Gulati, G. Singh, and F. Najmabadi,Biochem. Biophys. Res. Commun.,212, No. 3, 953–959 (1995).PubMedCrossRefGoogle Scholar
  12. 12.
    R. A. Jr. Pannettieri, R. G. Goldie, P. J. Rigby,et al., J. Pharmacol.,118, No. 1, 191–197 (1996).Google Scholar
  13. 13.
    M. Takimoto, K. Oda, Y. Sasaki, and T. Okada,Endocrinology,137, No. 11, 4520–4550 (1996).CrossRefGoogle Scholar
  14. 14.
    A. M. Vignola, G. Chiappara, P. Chanez,et al., Monaldi. Arch. Chest. Dis.,52, No. 2, 159–169 (1997).PubMedGoogle Scholar
  15. 15.
    S. R. White, D. P. Hathaway, J. G. Umans,et al., Am. Rev. Respir. Dis.,144, No. 2, 373–378 (1991).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • O. A. Lebed'ko
    • 1
    • 2
  • S. S. Timoshin
    • 1
    • 2
  1. 1.Siberian Division of the Russian Academy of Medical SciencesInstitute of Maternity and Child WelfareKhabarovsk
  2. 2.Far-Eastern State Medical UniversityKhabarovsk

Personalised recommendations