Free-radical oxidation during experimental pneumonia
- 25 Downloads
Lipid peroxidation in the lungs and plasma of albino rats was studied under normal conditions and during experimental pneumonia. In intact rats the content of lipid peroxidation products and the rate of their accumulation in lung homogenate is lower than in homogenates of other organs. Bivalent iron ions added to blood plasma did not induce chemiluminescence characteristic of lipid peroxidation. Experimental pneumonia intensifies production of active oxygen forms by alveolar macrophages and blood neutrophils and increases the content of lipid peroxidation products in lung homogenate. Combined application of antibiotics and antioxidant (vitamin E) during experimental pneumonia promotes normalization of free-radical oxidation and diminishes morphological alterations in the lungs.
Key wordspneumonia lipid peroxidation chemiluminescence
Unable to display preview. Download preview PDF.
- 1.Yu. A. Vladimirov and A. N. Archakov,Lipid Peroxidation in Biological Membranes [in Russian], Moscow (1972).Google Scholar
- 2.E. V. Gembitskii and V. G. Novozhenov,Klin. Med., No. 5, 7–12 (1994).Google Scholar
- 3.N. A. Didkovskii, Yu. A. Vladimirov, N. V. Reshetova, et al.,Pul'monologiya, No. 1, 24–34 (1995).Google Scholar
- 4.N. K. Zenkov, E. B. Men'shikova, and S. M. Shergin,Oxidative Stress: Diagnostics, Therapy, and Prevention [in Russian], Novosibirsk (1993).Google Scholar
- 5.M. B. Keniya, A. I. Lukash, and E. P. Gus'kov,Usp. Sovr. Biol.,113, No. 4, 456–470 (1993).Google Scholar
- 6.A. N. Kokosov, Yu. M. Goldenberg, and V. P. Mishchenko,Pul'monologiya, No. 1, 38–43 (1995).Google Scholar
- 7.E. A. Kost and M. I. Smenko, in:Proceedings of S. P. Botkin Hospital [in Russian], Moscow (1947), pp. 253–256.Google Scholar
- 8.N. V. Syromyatnikova, V. A. Goncharova, and T. V. Kotenko,Metabolic Activity of the Lungs [in Russian], Leningrad (1987).Google Scholar
- 9.R. R. Farkhutdinov and V. A. Likhovskikh,chemoluminescent Methods to Study Free Radical Oxidation in Biology and Medicine [in Russian], Ufa (1995).Google Scholar
- 13.S. J. Klebanoff, in:Inflammation. Basic Principles and Clinical Correlates, New York (1992), pp. 541–588.Google Scholar