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Accumulation of porphyrins in thyroid tissue and cells induced by σ-aminolevulinic acid

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

σ-Aminolevulinic acid and phenanthroline induced accumulation of metal-free porphyrins in homogenates of thyroid tissue and cells obtained after thyroidectomy. The rate of pigment synthesis considerably increased in specimens isolated from pathologically changed tissue, and the pigments were primarily located in cells. The results indicate that endogenous porphyrins can be used in the diagnosis and phototherapy of thyroid tumors.

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Authors and Affiliations

  1. Institute of Photobiology, National Academy of Sciences of Republic of Belarus, Minsk, USSR

    E. S. Lobanok, A. V. Vorobei & V. Ya. Rebeko

  2. Minsk Municipal Oncology Dispensary, Minsk, USSR

    E. S. Lobanok, A. V. Vorobei & V. Ya. Rebeko

Authors
  1. E. S. Lobanok
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  2. A. V. Vorobei
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  3. V. Ya. Rebeko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 222–225, August, 1999

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Lobanok, E.S., Vorobei, A.V. & Rebeko, V.Y. Accumulation of porphyrins in thyroid tissue and cells induced by σ-aminolevulinic acid. Bull Exp Biol Med 128, 854–856 (1999). https://doi.org/10.1007/BF02433833

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  • DOI: https://doi.org/10.1007/BF02433833

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