Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 2, pp 839–842 | Cite as

Adrenergic regulation of lymphocyte proliferative response in cultures with T-cell mitogens

  • Yu. I. Shilov
  • S. V. Gein
Microbiology and Immunology


The effects of epinephrine, β-adrenergic agonist terbutaline sulfate, and cAMP phosphodiesterase inhibitor theophylline on proliferative response of peripheral blood lymphocytes from healthy subjects were studied in cultures with phytohemagglutinin and concanavalin A. Both adrenergic agonists inhibited lymphocyte blastogenesis, but the effect of epinephrine was more pronounced.

Key Words

epinephrine β-adrenergic compounds lymphocyte blastogenesis 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • Yu. I. Shilov
    • 1
    • 2
  • S. V. Gein
    • 1
    • 2
  1. 1.Laboratory of Ecological Immunology, Institute of Ecology and Genetics of MicroorganismsUral Division of Russian Academy of SciencesPerm
  2. 2.Department of Microbiology and ImmunologyPerm' State UniversityPerm'Russia

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