Skip to main content
SpringerLink
Log in

Role of leukocytes in increased vascular permeability in inflammation

  • General Pathology and Pathologigal Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Carrageenan-induced acute aseptic peritonitis was used as a model of inflammation. In rats with irradiation-induced leukopenia, the immediate and delayed phases of increased vascular permeability in the inflammatory focus were mediated by leukocytes. In the immediate phase, lysosomal enzymes, reactive oxygen species, and cyclooxygenase and lipoxygenase metabolites of arachidonic acid are involved in the regulation of vascular permeability, while in the delayed phase, lysosomal enzymes and lipoxygenase derivatives play the major role. Dexamethasone sharply inhibits vascular permeability in both phases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. I. Bereznyakova and V. N. Kuznetsova,Farmakol. Toksikol.,51, No. 5, 62 (1988).

    CAS  Google Scholar 

  2. I. Vermesh and V. E. Ryzhenkov,Probl. Endokrinol,20, No. 3, 67–70 (1974).

    Google Scholar 

  3. Yu. I. Gubskii, A. E. Boldeskul, R. T. Primak,et al., Ukr. Biokhim. Zh.,61, No. 4, 94–99 (1989).

    PubMed  CAS  Google Scholar 

  4. A. M. Dygai and N. A. Klimenko,Inflammation and Hematopoiesis [in Russian], Tomsk (1992).

  5. N. A. Klimenko,Byull. Eksp. Biol. Med.,113, No. 1, 28–30 (1992).

    Article  CAS  Google Scholar 

  6. N. A. KlimenkoIbid.,113, No. 1, 249–253 (1993).

    Google Scholar 

  7. N. A. Klimenko, R. U. Lipshits, S. V. Tatarko,et al., Fiziol. Zh.,44, No. 4, 82 (1998).

    Google Scholar 

  8. N. A. Klimenko and E. A. Pavlova,Radiats,. Biol. Radioekol.,37, No. 5, 51–53 (1997).

    Google Scholar 

  9. N. A. Klimenko and G. Yu. Pyshnov,Byull. Eksp. Biol. Med.,115, No. 1, 29–30 (1993).

    Article  CAS  Google Scholar 

  10. Yu. N Kolchin, L. F. Popovich, L. N. Grabovskii,et al., Kardiologiya,30, No. 3, 72–75 (1990).

    PubMed  CAS  Google Scholar 

  11. V. A. Protsenko, S. I. Shpak, and V. V. Afanas'eva,Pat. Fiziol., No. 3, 41–43 (1984).

    Google Scholar 

  12. I. G. Colditz,Inflammation 12, 251–263 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. R. F. Lemanske, D. A. Guthman, H. Oerter,et al., J. Immunol.,130, 2837–2842 (1983).

    PubMed  Google Scholar 

  14. S. Moncada and A. Higgs,N. Engl. J. Med.,329, 2002–2012 (1993).

    Article  PubMed  CAS  Google Scholar 

  15. I. Olsson and P. Venge,Allergy,35, 1–13 (1980).

    PubMed  CAS  Google Scholar 

  16. C. V. Wedmore, and T. Y. Williams,Nature,289, No. 5799, 646–650 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathophysiology, Khar'kov State Medical University, Khar'kov, Russia

    N. A. Klimenko & E. A. Pavlova

Authors
  1. N. A. Klimenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Pavlova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 165–167, August, 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Klimenko, N.A., Pavlova, E.A. Role of leukocytes in increased vascular permeability in inflammation. Bull Exp Biol Med 128, 800–802 (1999). https://doi.org/10.1007/BF02433819

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02433819

Key words

Search

Navigation