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Effect of semax heptapeptide on rat heart activity during acute hypobaric hypoxia in the early postnatal period

  • General Pathology and Pathologigal Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of Semax heptapeptide on the resistance to acute hypobaric hypoxia and on hypoxic changes in the ECG chronotropic index were studied in 14- and 21-day-old pups. The resistance to hypoxia decreased with age. Hypoxic exposure caused bradycardia in both age groups. Semax reduced the bradycardiac reaction and exerted an antiarrhythmic effect without affecting the resistance to hypoxia.

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References

  1. Ya. V. Krushinskaya.Improvement of the Resistance to Hemorrage and Hypobaric Hypoxia by Complex of Regulatory Peptides, Abstract of Cand. Biol. Sci. dissertation, Moscow (1996).

  2. Recommendation for Experimental Study of Preparations, Offered for Clinical Tests as Antihypoxic Drugs [in Russian] Ed. L. D. Luk'yanova Moscow (1990).

  3. N. P. Shabalov, V. K. Yaroslavskii, D. A. Khodov, and V. A. Lyubimenko,Asphyxia in Neonates [in Russian], Leningrad (1990).

  4. I. P. Ashmarin, V. N. Nezavibat'ko, N. G. Levitskaya,et al., Neurosci. Res. Commun.,16, No. 2, 105–112 (1995).

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russian

    M. V. Maslova, Ya. V. Krushinskaya, A. S. Maklakova, P. V. Balan, Yu. B. Kuznetsov, N. A. Sokolova & I. P. Ashmarin

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  1. M. V. Maslova
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  2. Ya. V. Krushinskaya
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  3. A. S. Maklakova
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  4. P. V. Balan
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  5. Yu. B. Kuznetsov
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  6. N. A. Sokolova
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  7. I. P. Ashmarin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 161–164, August, 1999

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Maslova, M.V., Krushinskaya, Y.V., Maklakova, A.S. et al. Effect of semax heptapeptide on rat heart activity during acute hypobaric hypoxia in the early postnatal period. Bull Exp Biol Med 128, 797–799 (1999). https://doi.org/10.1007/BF02433818

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  • DOI: https://doi.org/10.1007/BF02433818

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