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Effect of blood loss on nitric oxide content in liver and mucosa and muscle layer of small intestine in rats

  • General Pathology and Pathologigal Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Moderate blood loss (20 ml/kg) increases NO content in the intestinal mucosa and muscle layer, and especially, in the liver, as revealed byin vivo nitric oxide (NO) binding with Fe2+-diethyldithiocarbamate complex yielding paramagnetic mononitrosyl iron complexes. Enhanced NO synthesis after blood loss prevents vascular spasm in the mucosa, thus maintaining blood circulation and effective absorption in the small intestine.

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 8, pp. 153–156, August, 1999

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Koval'skaya, K.S., Mordvintsev, P.I. & Vanin, A.F. Effect of blood loss on nitric oxide content in liver and mucosa and muscle layer of small intestine in rats. Bull Exp Biol Med 128, 791–793 (1999). https://doi.org/10.1007/BF02433816

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  • DOI: https://doi.org/10.1007/BF02433816

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