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Anatomy and Embryology

, Volume 182, Issue 4, pp 401–408 | Cite as

The effects of surgical section of the embryonic chick mandibular arch

  • R. R. J. Cousley
  • D. J. Wilson
Article

Summary

The embryonic chick mandibular arch was surgically sectioned in ovo on day 7 of incubation and the subsequent wound healing of the arch, together with the response of Meckel’s cartilage to fracture, was examined. The repair process observed (in contrast to that in adults) was characterised by minimal haematoma formation or cell death and the absence of formation of either cellular blastema or fracture callus. Re-epithelisation was complete within 48 h with no scar tissue formed. Continuity of Meckel’s cartilage, together with restoration of its histological appearance and that of the surrounding soft tissues, was re-established within 24 h in 88% of cases. In the case of the cartilage this was due to fusion of the matrix followed apparently by chondrocytic and perichondrial proliferation. This differs from the repair of embryonic long bone cartilages. In 12% of cases, however, mal-union or non-union of the cartilage resulted in mandibular arch deviation. This observation suggests that mandibular arch growth and morphogenesis may parallel the development of Meckel’s cartilage. Where cartilaginous non-union occurred, some irregularities in the pattern of the developing mandibular bones were evident, and it is argued that deformity in the cartilage may ultimately affect the length and shape of the adult mandible.

Key words

Meckel’s cartilage Wound healing Dysmorphogenesis Mandible Chick 

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References

  1. Bee J, Thorogood P (1980) The role of tissue interactions in the skeletogenic differentiation of avian neural crest cells. Dev Biol 78:47–62PubMedCrossRefGoogle Scholar
  2. Caplan AI (1987) Bone development and repair. Bioessays 6:171–175PubMedCrossRefGoogle Scholar
  3. Diewert VM (1980) The role of craniofacial growth in palatal shelf elevation. In Pratt RM, Christiansen RL (eds) Current research trends in prenatal craniofacial development. Elsevier, New York, pp 165–186Google Scholar
  4. Fell HB, Robinson R (1930) The development and phosphatase activity in vitro of the mandibular skeletal tissue of the embryonic fowl. Biochem J 24:1905–1921PubMedGoogle Scholar
  5. Hall BK (1982a) Mandibular morphogenesis and craniofacial malformations. J Craniofac Genet Dev Biol 2:309–322PubMedGoogle Scholar
  6. Hall BK (1982b) How is mandibular growth controlled during development and evolution? J Craniofac Genet Dev Diol 2:45–49Google Scholar
  7. Hamburger V, Hamilton HC (1951) A series of normal stages in development of the chick embryo. J Morphol 88:49–92CrossRefGoogle Scholar
  8. Hinchliffe JR, Johnson DR (1983) Growth of cartilage. In: Hall BK (ed) Cartilage, vol 2. Development, differentiation and growth. Academic Press, New York, pp 255–295Google Scholar
  9. Kavumpurath S, Hall BK (1989) In vitro reformation of the perichondrium from perichondrial-free Meckel’s cartilages of the embryonic chick. J Craniofac Genet Dev Biol 9:173–184PubMedGoogle Scholar
  10. Le Douarin NM (1982) The neural crest. Cambridge University Press, LondonGoogle Scholar
  11. McCullagh JJ, Gill P, Wilson DJ (1990) Repair of cartilaginous fractures during chick limb development. J Orthop Res 8:127–131PubMedCrossRefGoogle Scholar
  12. Niven JSF (1931) The repair in vitro of embryonic skeletal rudiments after experimental injury. J Pathol 34:307–324CrossRefGoogle Scholar
  13. Noden DM (1978) The control of avian cephalic neural crest cyto-differentiation. 1 Skeletal and connective tissues. Dev Biol 67:296–312PubMedCrossRefGoogle Scholar
  14. Noden D (1983) The role of the neural crest in patterning avian cranial, skeletal, connective and muscle tissues. Dev Biol 96:144–165PubMedCrossRefGoogle Scholar
  15. Rooney P, Archer CW, Wolpert L (1984) Morphogenesis of cartilaginous long bone rudiments. In: Trelstad RL (ed) The role of extracellular matrix in development. AR Liss, New York, pp 305–322Google Scholar
  16. Shaw IA, Ferguson MWJ (1987) Mechanisms and characteristics of embryonic wound healing: an experimental study in the chick. J Dent Res 66; 861Google Scholar
  17. Summerbell D (1976) A descriptive study of the rate of elongation and differentiation of the skeleton of the developing chick wing. J Embryol Exp Morphol 35:241–260PubMedGoogle Scholar
  18. Summerbell D, Hornbruch A (1981) The chick embryo — a standard against which to judge in vitro systems. In: Neubert D, Merker H-J (eds) Culture techniques — applicability for studies on prenatal differential and toxicity. Walter de Gruyter, Berlin, pp 529–539Google Scholar
  19. Teitelbaum SL (1985) Metabolic and other nontumorous disorders of bone. In: Kissane JM (ed) Anderson’s Pathology. Mosby, St Louis, pp 1705–1777Google Scholar
  20. Thorogood PV (1983) Morphogenesis of cartilage. In: Hall BK (ed) Cartilage, vol 2. Development, differentiation and growth. Academic Press, New York, pp 223–254Google Scholar
  21. Tyler MS (1988) Development of osteogenic and chondrogenic potentials along the mediolateral axis of the embryonic chick mandible. Arch Oral Biol 33:443–449PubMedCrossRefGoogle Scholar
  22. Tyler MS, Hall BK (1977) Epithelial influences on skeletogenesis in the mandible of the embryonic chick. Anat Rec 188:229–235PubMedCrossRefGoogle Scholar
  23. Wilson DJ, McNeill J, Hinchliffe JR (1989) Posterior half amputation of the chick wing bud: the response of the developing vasculature and subsequent wound healing. Anat Embryol 180:383–391PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. R. J. Cousley
    • 1
  • D. J. Wilson
    • 2
  1. 1.School of Biomedical Science/AnatomyThe Queen’s University of Belfast, The Medical Biology CentreBelfastNorthern Ireland
  2. 2.School of Clinical Dentistry/Dental SurgeryThe Queen’s University of Belfast, The Medical Biology CentreBelfastNorthern Ireland

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