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Analysis of bromantane pharmacological spectrum

Bulletin of Experimental Biology and Medicine volume 128, pages 1116–1118 (1999)Cite this article

Abstract

Bromantane (2[n-bromphenyl]aminoadamantane) in doses of 40–60 mg/kg had no effect on spontaneous motor activity of BALB/c mice in a Optovarimex apparatus and prevented freezing in the open field test, but stimulated motor activity in C57B1/6 mice. It is concluded that psychostimulatory and anxiolytic effects are present in the spectrum of the pharmacological activity of bromantane.

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References

  1. Yu. A. Blednov, M. M. Kozlovskaya, M. Maula,et al., Current Problems of Experimental and Clinical Pharmacology [in Russian], V. E. Novikov, Ed., Smolensk (1994), pp. 13–15.

  2. T. S. Galushina, T. A. Fadeeva, and N. G. Artsimovich,Immunologiya, No. 8, 28–30 (1996).

    Google Scholar 

  3. T. S. Galushina, T. A. Fadeeva, and N. G. Artsimovich,Ibid.Immunologiya, 31–33.

  4. T. B. Grekhova, R. R. Gainetdinov, T. D. Sotnikova,et al., Byull. Eksp. Biol. Med.,119, No. 3, 302–304 (1995).

    CAS  Google Scholar 

  5. S. V. Krapivin, S. A. Sergeeva, and I. S. Morozov, ——Ibid.116, No. 11, 515–518 (1993).

    CAS  Google Scholar 

  6. V. S. Kudrin, S. A. Sergeeva, L. M. Krasnykh,et al., Eksp. Klin. Farmakol., 58, No. 4, 8–10 (1995).

    PubMed  CAS  Google Scholar 

  7. M. D. Mashkovskii and V. A. Al'tshuller,Khim. Farm. Zh.,14, No. 5, 7–9 (1980).

    CAS  Google Scholar 

  8. S. A. Sergeeva, S. V. Krapivin, A. S. Losey, and I. S. Morozov,Farmakol. Toksikol.,58, 305–308 (1995).

    Google Scholar 

  9. S. B. Seredenin and A. A. Vedernikov,Byull. Eksp. Biol. Med.,88, No. 7, 38–40 (1979).

    CAS  Google Scholar 

  10. S. B. Seredenin, T. A. Voronina, G. G. Neznamov,et al., Vestn. Akad. Med. Nauk, No. 11, 47–52 (1998).

    Google Scholar 

  11. S. B. Seredenin and Yu. A. Blednov,Phys. Chem. Biol. Med., No. 1, 53–60 (1993).

    CAS  Google Scholar 

  12. R. I. Tallaria and R. B. Murray,Manual of Pharmacologic Calculation with Computer Programs, New York (1986).

Download references

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Authors and Affiliations

  1. Laboratory of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    S. B. Seredenin & A. G. Miramedova

Authors
  1. S. B. Seredenin
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  2. A. G. Miramedova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 529–531, November, 1999

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Seredenin, S.B., Miramedova, A.G. Analysis of bromantane pharmacological spectrum. Bull Exp Biol Med 128, 1116–1118 (1999). https://doi.org/10.1007/BF02433415

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  • DOI: https://doi.org/10.1007/BF02433415

Key words

  • bromantane
  • inbred mice
  • anxiolytic