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Effect of new anxiolytic CM-346 on bioelectrical activity of cerebral cortex in MR and MNRA rats

  • Physiology
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Abstract

The effect of 2-[2-(morpholin)ethylthio]-5-ethoxybenzimidazole (CM-346) on the EEG of MR and MNRA rats was compared with that of diazepam. Both CM-346 and diazepam reversed stress-induced changes in bioelectrical activity after intraperitoneal injection of 0.9% NaCl. In MR and MNRA rats both drugs decreased the EEG spectral power in the high-frequency θ-band (7.5–8.2 Hz). In MR rats, CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. The data suggest that CM-346 exerts antistressor and anxiolytic effects in animals with passive reactions to emotional stress.

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Authors and Affiliations

  1. Department of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    S. N. Kozhechkin, I. V. Viglinskaya & S. B. Seredenin

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

    N. E. Sviderskaya, T. A. Korol'kova, O. Kh. Koshtoyants & R. G. Kozhedub

Authors
  1. S. N. Kozhechkin
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  2. I. V. Viglinskaya
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  3. S. B. Seredenin
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  4. N. E. Sviderskaya
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  5. T. A. Korol'kova
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  6. O. Kh. Koshtoyants
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  7. R. G. Kozhedub
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 500–503, November, 1999

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Kozhechkin, S.N., Viglinskaya, I.V., Seredenin, S.B. et al. Effect of new anxiolytic CM-346 on bioelectrical activity of cerebral cortex in MR and MNRA rats. Bull Exp Biol Med 128, 1090–1093 (1999). https://doi.org/10.1007/BF02433407

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  • DOI: https://doi.org/10.1007/BF02433407

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