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Bulletin of Experimental Biology and Medicine

, Volume 127, Issue 4, pp 374–376 | Cite as

Effects of exogenous glucocorticoids on colony-forming activity of the bone marrow under cytotoxic exposure

  • I. A. Khlusov
  • T. Yu. Raskovalova
  • A. M. Dygai
  • E. D. Gol'dberg
Pharmacology and Toxicology

Abstract

Experiments on CBA/CaLac mice receiving a half-maximum tolerated dose of 5-fluorouracil demonstrated an inhibitory effect of physiological concentrations of dexamethasone (127×10−9M) on colony-forming activity of erythroid and granulomonocytic precursors in intact and regenerating bone marrow. Dexamethasone exhibited protective effects on granulocyte, macrophage, and fibroblast precursors during maximum myelosuppression. Various responses of hemopoietic progenitor cells to exogenous corticosteroidin vitro are probably determined by their functional state.

Key Words

dexamethasone hemopoietic precursors 5-fluorouracil 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • I. A. Khlusov
    • 1
  • T. Yu. Raskovalova
    • 1
  • A. M. Dygai
    • 1
  • E. D. Gol'dberg
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesTomsk

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