Effects of exogenous glucocorticoids on colony-forming activity of the bone marrow under cytotoxic exposure
Experiments on CBA/CaLac mice receiving a half-maximum tolerated dose of 5-fluorouracil demonstrated an inhibitory effect of physiological concentrations of dexamethasone (127×10−9M) on colony-forming activity of erythroid and granulomonocytic precursors in intact and regenerating bone marrow. Dexamethasone exhibited protective effects on granulocyte, macrophage, and fibroblast precursors during maximum myelosuppression. Various responses of hemopoietic progenitor cells to exogenous corticosteroidin vitro are probably determined by their functional state.
Key Wordsdexamethasone hemopoietic precursors 5-fluorouracil
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- 1.E. D. Gol'dberg, A. M. Dygai, and I. A. Khlusov,Role of the Autonomic Nervous System in Regulation of Hemopoiesis [in Russian], Tomsk (1997).Google Scholar
- 2.E. D. Gol'dberg, A. M. Dygai, and V. P. Shakhov,Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).Google Scholar
- 3.Kinetic Aspects of Hemopoiesis [in Russian], Eds. G. I. Kozinets and E. D. Gol'dberg, Tomsk (1982).Google Scholar