Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 1, pp 668–670 | Cite as

Effect of cerebrospinal fluid preparation from opiate addicts on anxiety level in rats

  • N. E. Ordyan
  • V. Yu. Vasil'ev
  • N. N. Nesterov
  • V. V. Rakitskaya
  • I. A. Garina
  • S. G. Pivina
  • P. A. Pirumov
  • V. G. Shalyapina
Physiology
  • 22 Downloads

Abstract

Intranasal administration of a preparation isolated from the cerebrospinal fluid of opium addicts in the initial stage of withdrawal to rats reduced their exploratory activity and increased anxiety and nociceptive threshold in a tail-shock test.

Key words

opium addiction rats anxiety nociception 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • N. E. Ordyan
    • 1
  • V. Yu. Vasil'ev
    • 1
  • N. N. Nesterov
    • 1
  • V. V. Rakitskaya
    • 1
  • I. A. Garina
    • 1
  • S. G. Pivina
    • 1
  • P. A. Pirumov
    • 1
  • V. G. Shalyapina
    • 1
  1. 1.I. P. Pavlov Institute of PhysiologyRussian Academy of Medical SciencesSt. Petersburg

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