Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 4, pp 1015–1017 | Cite as

Some mechanisms of antiarrhythmic effect of phosphoenolpyruvate

  • V. P. Balashov
  • E. A. Sosunov
  • L. A. Balykova
  • L. N. Sernov
Pharmacology and Toxicology
  • 19 Downloads

Abstract

Depolarization automaticity was modeled on the papillary muscle from the guinea pig heart. Phosphoenolpyruvate (0.1 mM) 2-fold decreased the high-frequency calcium-dependent automaticity, but only weakly affected frequency of action potentials, whose upstroke was formed by fast sodium current or had a mixed nature. Phosphoenolpyruvate shifted the diastolic potential toward negative values, which depended on the amplitude of depolarization step. These effects developed 10–15 min after application of the preparation.

Key Words

phosphoenolpyruvate depolarization automaticity action potential 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    V. P. Balashov, Ya. V. Kostin, D. G. Sedova, et al.,Byull. Eksp. Biol. Med.,115, No. 6, 629–630 (1993).CrossRefGoogle Scholar
  2. 2.
    R. Z. Gainulin and N. I. Kukushkin,Biofizika,22, 505–511 (1977).Google Scholar
  3. 3.
    V. V. Gatsura,Pharmacological Correction of Ischemic Myocardium [in Russian], Moscow (1993).Google Scholar
  4. 4.
    N. I. Kukushkin,The Mechanisms of Generation of Experimental Sources of Autowaves in the Myocardium and Principles of Screening of Antiarrhythmic Agents, Abstract of Doct. Biol. Sci. Dissertation, Pushchino (1985).Google Scholar
  5. 5.
    V. I. Porotikov, A. V. Lazarev, and R. A. Glezer,Usp. Fiziol. Nauk, No. 3, 42–62 (1984).Google Scholar
  6. 6.
    L. N. Sernov,Pharmacological Correction of Regional Metabolic Acidosis and Restriction of Necrosis Zone in Acute Myocardial Ischemia, Abstract of Doct. Med. Sci. Dissertation, Kupavna (1991).Google Scholar
  7. 7.
    L. N. Sernov, L. N. Beregovykh, E. R. Davidov, and V. V. Gatsura,Chemistry, Pharmacology, and Biotechnology of Cytochrome C [in Russian], Moscow (1997).Google Scholar
  8. 8.
    L. N. Sernov, Yu. B. Rozonov, and V. V. Gatsura,Eksp. Klin. Farmakol., No. 4, 13–15 (1992).Google Scholar
  9. 9.
    V. V. Gatsura, L. N. Sernov, and J. B. Rozonov,J. Mol. Cell. Cardiol.,24, Suppl. 1, 186 (1992).Google Scholar
  10. 10.
    M. Janse, F. J. van Capelle, H. Morsink, et al.,Circ. Res.,47, No. 2, 151–165 (1980).PubMedGoogle Scholar
  11. 11.
    A. K. Markov, N. C. Oglethorpe, T. M. Blake, et al.,Am. Heart J.,100, 639–646 (1980).PubMedCrossRefGoogle Scholar
  12. 12.
    L. H. Opie, D. Nathan, and W. F. Lubbe,Am. J. Cardiol.,43, 131–148 (1979).PubMedCrossRefGoogle Scholar
  13. 13.
    E. M. Vaughan-Williams,J. Clin. Pharmacol.,32, 964–977 (1992).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • V. P. Balashov
    • 1
  • E. A. Sosunov
    • 1
  • L. A. Balykova
    • 1
  • L. N. Sernov
    • 1
  1. 1.Department of PharmacologyMordovian State UniversitySaransk

Personalised recommendations