Some mechanisms of antiarrhythmic effect of phosphoenolpyruvate
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Depolarization automaticity was modeled on the papillary muscle from the guinea pig heart. Phosphoenolpyruvate (0.1 mM) 2-fold decreased the high-frequency calcium-dependent automaticity, but only weakly affected frequency of action potentials, whose upstroke was formed by fast sodium current or had a mixed nature. Phosphoenolpyruvate shifted the diastolic potential toward negative values, which depended on the amplitude of depolarization step. These effects developed 10–15 min after application of the preparation.
Key Wordsphosphoenolpyruvate depolarization automaticity action potential
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