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Bulletin of Experimental Biology and Medicine

, Volume 128, Issue 4, pp 981–984 | Cite as

Enhanced expression of sarcoplasmic reticulum Ca2+-ATPase gene plays a role in protective effects of nitric oxide

  • N. P. Aimasheva
  • E. B. Malenyuk
  • E. B. Manukhina
  • G. L. Khaspekov
  • V. D. Mikoyan
  • L. N. Kubrina
  • A. F. Vanin
  • I. Yu. Malyshev
General Pathology and Pathological Physiology

Abstract

This study verifies the hypothesis that NO-dependent regulation of sarcoplasmic reticulum Ca2+-ATPase gene (SERCA) plays an important role in preventing Ca2+ overload after exposure to damaging factors. The data confirmed NO-dependent activation of SERCA expression and important role of this mechanism in the reduction of calcium overload.

Key words

nitric oxide Ca2+-ATPase expression reperfusion physical exercise 

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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • N. P. Aimasheva
    • 1
  • E. B. Malenyuk
    • 1
  • E. B. Manukhina
    • 1
  • G. L. Khaspekov
    • 2
  • V. D. Mikoyan
    • 3
  • L. N. Kubrina
    • 3
  • A. F. Vanin
    • 2
  • I. Yu. Malyshev
    • 1
  1. 1.Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow
  2. 2.Russian Cardiology Research-and-Production ComplexMinistry of Health of the Russian FederationMoscow
  3. 3.Institute of Chemical PhysicsRussian Academy of ScienceMoscow

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