Abstract
Adaptation to hypoxia and short-term immobilization stress, as well as preconditioning with Rhodiolae rosea extract produces pronounced antiarrhythmic and cardioprotective effects in the model of adrenergic damage to the heart. Preliminary blockade of opioid receptor significantly decreases the protective effect of adaptation. Using selective opiate receptor antagonists (naltrindole, ICI 174,864, and norbinaltorphimine) we show that the antiarrhythmic effect of adaptation is mediated predominantly via activation ofk-receptors, and to a lesser extent μ-and σ-receptors.
Similar content being viewed by others
References
Yu. B. Lishmanov and L. N. Maslov,Opioid Neuropeptides, Stress, and Adaptive Protection of the Heart [in Russian], Tomsk (1994).
F. Z. Meerson,Adaptation, Stress, and Prophylaxis [in Russian], Moscow (1981).
F. Z. Meerson, in:Physiology of Adaptive Processes: Handbook on Physiology [in Russian], Moscow (1986), pp. 521–631.
A. S. Saratikov and E. A. Krasnov,Rhodiolae Rosea as an Efficient Medicinal Plant [in Russian], Tomsk (1987).
M. Broccardo and G. Improta,Eur. J. Pharmacol.,218, 69–72 (1992).
R. Cotton, M. G. Giles, L. Miller,et al.,,97, 331–332 (1984).
A. Fleckenstein, J. Janre, H. J. Döring,et al., in:Recent Advances in Studies on Cardiac Structure and Metabolism, A. Fleckenstein and G. Rona (Eds.), Baltimore (1975).
X. D. Huang and T. M. Wong,Life Sci.,48, No. 11, 1101–1107 (1991).
S. A. Krumius, A. I. Faden, and G. Feuerstein,Biochem. Biophys. Res. Commun.,127, 120–128 (1985).
K. P. Mayfield and L. G. D'Alecy,Brain Res.,582, 226–231 (1992).
M. J. Millan, A. Czlonkowski, A. Lipkowski,et al., J. Pharmacol. Exp. Ther.,251, No. 1, 342–350 (1989).
D. G. Miller and S. Mallov,Pharmacol. Biochem. Behav.,7, No. 2, 139–145 (1977).
P. S. Portoghese, A. W. Lipkowski, and A. E. Takemori,Life Sci.,40, 1287–1291 (1987).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 2, pp. 167–170, February, 1999
Rights and permissions
About this article
Cite this article
Lishmanov, Y.B., Maimeskulova, L.A., Uskina, E.V. et al. Opiatergic mechanisms of cardioprotective and antiarrhythmic effects of adaptation. Bull Exp Biol Med 127, 151–154 (1999). https://doi.org/10.1007/BF02433099
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02433099