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Bulletin of Experimental Biology and Medicine

, Volume 127, Issue 2, pp 137–139 | Cite as

Adaptive capacity of granulocytic bone marrow stem cells in preleukemic AKR mice

  • E. D. Gol'dberg
  • Yu. P. Bel'skii
  • M. G. Danilets
  • A. M. Dygai
  • L. A. Kosnyreva
  • S. A. Kusmartsev
  • I. A. Khlusov
General Pathology and Pathological Physiology

Abstract

In leukemia-prone AKR mice, adaptation to 10-h immobilization stress increases the content of sialoadhesin-positive macrophages to the level of intact (CBA×AKR)F1 hybrids. Hybrid mice responds to stress by a slight reduction of this parameter. The contents of granulocytic hemopoietic islets and committed granulomonocyte precursors in the bone marrow after stress undergo opposite changes. Unlike hybrids, granulocytopoiesis in AKR mice is not activated by stress.

Key Words

sialoadhesin hemopoietic islets granulocyte-macrophagic precursors bone marrow stress 

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References

  1. 1.
    E. D. Gol'dberg, A. M. Dygai, V. V. Udut,et al., Structural Organization of Life-Supporting Systems in the Norm and Pathology [in Russian], Tomsk (1996).Google Scholar
  2. 2.
    E. D. Gol'dberg, A. M. Dygai, and I. A. Khlusov,Role of Autonomic Nervous System in the Regulation of Hemopoiesis [in Russian], Tomsk (1997).Google Scholar
  3. 3.
    E. D. Gol'dberg, A. M. Dygai, and V. P. Shakhov,Methods of Tissue Cultures in Hematology [in Russian], Tomsk (1992).Google Scholar
  4. 4.
    E. D. Gol'dberg, I. A. Khlusov, A. M. Dygai, and V. I. Agafonov,Byull. Eksp. Biol. Med.,116, No. 11, 457–460 (1993).Google Scholar
  5. 5.
    B. Burek and I. Hrzak,Immunol. Lett.,45, 185–188 (1995).PubMedCrossRefGoogle Scholar
  6. 6.
    P. R. Croker and S. Gordon,J. Exp. Med.,162, 993–1014 (1985).CrossRefGoogle Scholar
  7. 7.
    P. R. Croker and S. Gordon,,169, 1333–1346 (1989).CrossRefGoogle Scholar
  8. 8.
    A. G. Doyle, G. Herbein, L. J. Montaner,et al., Eur. J. Immunol.,24, 1441–1445 (1994).PubMedGoogle Scholar
  9. 9.
    S. Y. Kim, L. N. Evans, F. G. Malik, and R. V. Rouse,J. Virol.,65, 6238–6241 (1991).PubMedGoogle Scholar
  10. 10.
    A. S. McWilliam, P. Tree, and S. Gordon,Proc. Natl. Acad. Sci. USA,89, 10522–10526 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    T. K. Van der Berg, I. van Die, Ch. R. de Lavalette,et al., J. Immunol.,157, 3130–3138 (1996).PubMedGoogle Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • E. D. Gol'dberg
    • 1
  • Yu. P. Bel'skii
    • 2
  • M. G. Danilets
    • 2
  • A. M. Dygai
    • 1
  • L. A. Kosnyreva
    • 1
  • S. A. Kusmartsev
    • 2
  • I. A. Khlusov
    • 1
  1. 1.Institute of PharmacologySiberian Division of the Russian Academy of Medical SciencesUSSR
  2. 2.Laboratory of Biomedical Experimental Modeling, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesUSSR

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