Characteristics of the liver microsomal membranes in mice with genetically determined accelerated aging
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The liver membranes of SAMP mice with accelerated aging display increased inducibility of peroxide processes at early stages of life (2 months) and an initially higher level of MDA at later stages (8 months). In comparison with the liver membranes of the control SAMR strain, liver membranes of rapidly aging animals are characterized by more dense packing (higher microviscosity), increasing with age, judging from the eximerization of the membrane-binding fluorescent probe pyrene. Therefore, the differences in LPO and membranous bilayer packing occur in SAMP mice at early stages of development (earlier than the neurological parameters) and contribute to specific functioning of membrane-associated enzymes.
Key Wordsage-specific changes SAM mice lipid peroxidation pyrene eximerization
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