Bulletin of Experimental Biology and Medicine

, Volume 127, Issue 1, pp 66–68 | Cite as

Characteristics of the liver microsomal membranes in mice with genetically determined accelerated aging

  • M. O. Yuneva
  • E. M. Aleksandrova
  • E. G. Kurella
  • A. A. Boldyrev
Genetics
  • 16 Downloads

Abstract

The liver membranes of SAMP mice with accelerated aging display increased inducibility of peroxide processes at early stages of life (2 months) and an initially higher level of MDA at later stages (8 months). In comparison with the liver membranes of the control SAMR strain, liver membranes of rapidly aging animals are characterized by more dense packing (higher microviscosity), increasing with age, judging from the eximerization of the membrane-binding fluorescent probe pyrene. Therefore, the differences in LPO and membranous bilayer packing occur in SAMP mice at early stages of development (earlier than the neurological parameters) and contribute to specific functioning of membrane-associated enzymes.

Key Words

age-specific changes SAM mice lipid peroxidation pyrene eximerization 

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • M. O. Yuneva
    • 1
  • E. M. Aleksandrova
    • 1
  • E. G. Kurella
    • 2
  • A. A. Boldyrev
    • 2
  1. 1.International Biotechnology CenterM. V. Lomonosov Moscow State UniversityMoscow
  2. 2.Laboratory of Clinical Neurochemistry, Institute of NeurologyRussian Academy of Medical SciencesMoscow

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