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Induced cell death and its role in hemopoietic hypoplasia after cytostatic treatment

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The morphological signs of apoptosis in the bone-marrow cells and thymocytes, indices of cellularity in these organs and in peripheral blood and the absolute number of committed bone marrow cells-precursors have been studied on CBA mice injected with Etoposid (1/2 LD50). The results of the study suggest that reduced cellular counts observed in the hemopoietic organs 3–6 h after the cytostatic injection are due to Etoposid-induced apoptosis.

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk

    E. D. Gol'dberg, G. V. Karpova, E. A. Timina & I. A. Khlusov

Authors
  1. E. D. Gol'dberg
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  2. G. V. Karpova
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  3. E. A. Timina
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  4. I. A. Khlusov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 39–42, January 1999

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Gol'dberg, E.D., Karpova, G.V., Timina, E.A. et al. Induced cell death and its role in hemopoietic hypoplasia after cytostatic treatment. Bull Exp Biol Med 127, 33–36 (1999). https://doi.org/10.1007/BF02432794

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  • DOI: https://doi.org/10.1007/BF02432794

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