, Volume 12, Issue 2, pp 77–81 | Cite as

Pharmacological approaches to the aging brain: In vivo and in vitro model systems

  • Antonia Vernadakis


Aging Brain Pharmacological Approach 
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  1. 1.
    Vernadakis, A.: The aging brain, in Symposium on the Aging Process, Clinics in Geriatric Medicine, Vol. 1, edited by Geokas, M., Philadelphia, Saunders, 1985, pp. 61–94.Google Scholar
  2. 2.
    Timiras, P.S.: Aging of the nervous system, in Physiological Basis of Aging and Geriatrics, Chapters 9, 10, edited by Timiras, P.S., New York, MacMillan Publ. Co., 1988, pp. 123–155.Google Scholar
  3. 3.
    Bickford, P.C., Hoffer, B.J., and Freedman, R.: Interaction of norepinephrine with Purkinje cell responses to cerebellar afferent inputs in aged rats. Neurobiol. of Aging, 6: 89–94, 1985.CrossRefGoogle Scholar
  4. 4.
    Bickford, P.C., Hoffer, B.J., and Freedman, R.: Diminished interaction of norepinephrine with climbing fiber inputs to cerebellar Purkinje neurons in aged Fischer 344 rats. Brain Res., 385: 405–410, 1986.PubMedCrossRefGoogle Scholar
  5. 5.
    Parfitt, K.D.: Age-related electrophysiological changes in cerebellar noradrenergic receptors. AGE, 11: 120–127, 1988.Google Scholar
  6. 6.
    Brooks, V.B.: Cerebellar functions in motor control. Hum. Neurobiol., 2: 251–260, 1984.PubMedGoogle Scholar
  7. 7.
    Gilbert, P.F.C., and Thach, W.T.: Purkinje cell activity during motor learning. Brain Res., 128: 309–328, 1977.PubMedCrossRefGoogle Scholar
  8. 8.
    Watson, M., and McGelligott, J.G.: Cerebellar norepinephrine depletion and impaired acquisition of specific locomotor tasks in rats. Brain Res., 296: 129–138, 1984.PubMedCrossRefGoogle Scholar
  9. 9.
    Hoffer, B.J., Rose, G., Parfitt, K., Freedman, R., and Bickford-Wimer, P.C.: Age-related changes in cerebellar noradrenergic function. Ann. N.Y. Acad. Sci., 515: 269–286, 1988.PubMedGoogle Scholar
  10. 10.
    Hoffer, B., Seiger, A., Ljungborg, T., and Olson, L.: Electrophysiological and cytological studies of brain hemografts in the anterior chamber of the eye: Maturation of cerebellar cortex in oculo. Brain Res., 79: 165–184, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Hoffer, B., Olson, L., Seiger, A., and Bloom, F.E.: Formation of functional adrenergic input to intraocular cerebellar grafts: Ingrowth of inhibitory sympathetic fibers. J. Neurobiol., 6: 565–585, 1975.PubMedCrossRefGoogle Scholar
  12. 12.
    Granholm, A.C., Gerhardt, G.A., Eriksdotter-Nilsson, M., Bickford-Wimer, P.C., Palmer, M.R., Seiger, A., Olson, L., and Hoffer, B.J.: Age-related changes in cerebellar noradrenergic pre-and postsynaptic mechanisms: Intrinsic vs. extrinsic determinants evaluated with brain grafts in oculo. Brain Res., 423: 71–78, 1987.PubMedCrossRefGoogle Scholar
  13. 13.
    Bickford-Wimer, P.C., Miller, J.A., Freedman, R., and Rose, G.: Age-related reduction in responses of rat hippocampal neurons to locally applied monoamines. Neurobiol. of Aging, 9: 173–179, 1988.Google Scholar
  14. 14.
    Vernadakis, A., Davies, D.L., and Gremo, F.L.: Neural culture: A tool to study cellular neurotoxicity, in Neurotoxicology, edited by Blom, K., and Manzo, R., New York, Marcell Dekker, Inc., 1985, pp. 559–583.Google Scholar
  15. 15.
    Culver, B., and Vernadakis, A.: Effects of anticonvulsant drugs on chick embryonic neurons and glia in cell culture. Devel. Neurosci., 2: 74–85, 1979.Google Scholar
  16. 16.
    Sakellaridis, N., Mangoura, D., and Vernadakis, A.: Effects of opiates on the growth of neuron-enriched cultures from chick embryonic brain. Int. J. Devel. Neurosci., 4: 293–302, 1986.CrossRefGoogle Scholar
  17. 17.
    Davies, D., and Vernadakis, A.: Effects of ethanol on cultured glial cells: Proliferation and glutamine synthetase activity. Devel. Brain Res., 16: 27–35, 1984.CrossRefGoogle Scholar
  18. 18.
    Norenberg, M.D., and Martinez-Hernandez, A.: Fine structural localization of glutamine synthetase in astrocytes of the rat brain. Brain Res., 161: 303–310, 1979.PubMedCrossRefGoogle Scholar
  19. 19.
    Vernadakis, A.: Changes in astrocytes with aging, in Astrocytes, Biochemistry, Physiology, and Pharmacology, Vol. 2, edited by Fedoroff, S., and Vernadakis, A., New York, Academic Press, 1986 pp. 377–407.Google Scholar
  20. 20.
    Vernadakis, A., Mangoura, A., Sakkelaridis, N., and Linderholm, S.: Glial cells dissociated from newborn and aged mouse brain. J. Neurosci. Res., 11:253–262, 1984.PubMedCrossRefGoogle Scholar
  21. 21.
    Vernadakis, A., Davies, D., Sakellaridis, N., and Mangoura, D.: Growth patterns of glial cells dissociated from newborn and aged mouse brain with cell passage. J. Neurosci. Res., 15: 79–85, 1986.PubMedCrossRefGoogle Scholar
  22. 22.
    Poduslo, S.E., and Norton, W.T.: Isolation and some chemical properties of oligodendroglia from calf brain. J. Neurochem., 19: 727–736, 1972.PubMedGoogle Scholar
  23. 23.
    Hertz, L., and Schousboe, A.: Primary cultures of GABAergic and glutamatergic neurons as model systems to study neurotransmitter functions. I. Differentiated cells, in Model Systems of Development and Aging of the Nervous System, edited by Vernadakis, A., Privat, A., Lauder, J.M., Timiras, P.S., and Giacobini, E., Boston, Martinus Nijhoff Publ., 1987, pp. 19–32.Google Scholar
  24. 24.
    Coyle, J.T., Bird, S.J., Evans, R.H., Gulley, R.L., Nadler, J.V., Nicklas, W.J., and Olney, J.W.: Excitatory amino acid neurotoxins: Selectivity, specificity, and mechanisms of action. Neurosci. Res. Pro. Bull., 19: 331–427, 1981.Google Scholar
  25. 25.
    Vernadakis, A.: Neuron-glia interactions. Int. Rev. Neurobiology. Vol. 30, Chap. 5, 1989 (in press).Google Scholar
  26. 26.
    Vernadakis, A., and Sakellaridis, N.: Role of glial cells in neurotransmission mechanisms, in Progress in Neuroendocrinology, edited by Parvez, H., Parvez, S., and Gupta, D., The Netherlands, VNU Press, 1985, pp. 17–44.Google Scholar
  27. 27.
    Cotman, C.W., and Scheff, S.W.: Compensatory synapse growth in aged animals after neuronal death. Mech. Aging Devel., 9: 103–117, 1979.CrossRefGoogle Scholar
  28. 28.
    Neuronal Plasticity, edited by Cotman, C.W., New York, Raven Press, 1978.Google Scholar
  29. 29.
    Cotman, C.W., and Lynch, G.S.: Reactive synaptogenesis in the adult nervous system, in Neuronal Recognition, edited by Barondes, S., New York, Plenum Press, 1976, pp. 69–108.Google Scholar
  30. 30.
    Cotman, C.W., and Nadler, J.V.: Reactive synaptogenesis in the hippocampus, in Neuronal Plasticity, edited by Cotman, C.W., New York, Raven Press, 1978, pp. 227–271.Google Scholar

Copyright information

© American Aging Association, Inc. 1989

Authors and Affiliations

  • Antonia Vernadakis
    • 1
  1. 1.Departments of Psychiatry and PharmacologyUniversity of Colorado, School of MedicineDenver

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