Antioxidant Curcuma extracts decrease the blood lipid peroxide levels of human subjects

Abstract

Extracts of the rhyzome of Curcuma longa are widely used as food additives in India and other Asiatic and Central American countries. Moreover, it has been recently shown that these extracts (“turmeric”), as well as “curcumin” and related phenolic compounds isolated from Curcuma, have a powerful lipid anti-oxidant action, when tested in in vitro systems. This justifies the present attempt to find out whether hydroalcoholic extracts of Curcuma longa also exert an antioxidant effect in human subjects. Our data show that a 45-day intake (by healthy individuals ranging in age from 27 to 67 years) of Curcuma hydroalcoholic extract (at a daily dose equivalent to 20 mg of curcumine) results in a significant decrease in the levels of serum lipid peroxides. These peroxides probably play an important pathogenic role in normal senescence and age-related diseases such as atherosclerosis. Therefore, hydroalcoholic extracts of Curcuma longa (that have very low toxicity and have been cleared as food additives in the above countries) may find use in future preventive geriatrics after further clinical studies.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Harman, D.: Aging: A theory-based on free radical and radiation chemistry. J. Gerontol., 11: 298–300, 1956.

    PubMed  CAS  Google Scholar 

  2. 2.

    Harman, D.: The biological clock: The mitochondria? J. Am. Geriatr. Soc. 20: 145–147, 1972.

    PubMed  CAS  Google Scholar 

  3. 3.

    Miquel, J., Economos A.C., Fleming, J.E., Bensch, K.G., Arian, H., and Johnson, J.E., Jr.: Mitochondrial role in cell aging. Exp. Gerontol. 15: 575–591, 1980.

    PubMed  CAS  Article  Google Scholar 

  4. 4.

    Henning, B., and Chow, C.K.: Lipid peroxidation and endothelial cell injury: Implications in atherosclerosis. Free Rad. Biol. Med. 4: 99–106, 1988.

    Article  Google Scholar 

  5. 5.

    Sharma, O.P.: Antioxidant activity of cumumin and related compounds. Biochem. Pharmacol., 25: 1811–1812, 1976.

    PubMed  CAS  Article  Google Scholar 

  6. 6.

    Toda, S.: Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa. L. Chem. Pharm. Bull. 33: 1725–1728, 1985.

    PubMed  CAS  Google Scholar 

  7. 7.

    Ohkava, M., Ohishi, N., and Yagi, K.: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351–358, 1979.

    Article  Google Scholar 

  8. 8.

    Bhavani Shankar, T.N., Shanhta, N.V., Ramesh, H.P., Murthy, I.A.S., Murthy, V.S.: Toxicity studies on turmeric (Curcuma Ionga): Acute toxicity studies in rats, guinea pigs & monkeys. Indian J. Exp. Biol. 18: 73–75, 1980.

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ana Ramirez-Boscá.

About this article

Cite this article

Ramirez-Boscá, A., Soler, A., Carrión Gutierrez, M.A. et al. Antioxidant Curcuma extracts decrease the blood lipid peroxide levels of human subjects. AGE 18, 167–169 (1995). https://doi.org/10.1007/BF02432631

Download citation

Keywords

  • Lipid Peroxide
  • Curcumin
  • Serum Lipid
  • Food Additive
  • Blood Lipid