, Volume 12, Issue 1, pp 1–5 | Cite as

Hyperoxia and aging increase the guanylate cyclase activity of the rat lung

  • C. Santa Maria
  • E. Revilla
  • I. Fabregat
  • A. Machado


Age-associated changes on guanylate cyclase activity in the lung were investigated using male Wistar rats of ages ranging from 1 to 24 months. In 3 to 24 month old rats there is an increase about 3–4 fold in the activity of this enzyme. The effects of hyperoxia on lung guanylate cyclase activity in adult rats (3 months) were also studied. After 7 days of hyperoxia an increase (about 5 fold) in the activity of this enzyme was found. The relation of these data with the free radical theory of aging is discussed.


Radical Theory Cyclase Activity Guanylate Cyclase Free Radical Theory Guanylate Cyclase Activity 
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Copyright information

© American Aging Association, Inc. 1989

Authors and Affiliations

  • C. Santa Maria
    • 1
  • E. Revilla
    • 1
  • I. Fabregat
    • 1
  • A. Machado
    • 1
  1. 1.Departamento de Bioquimica, Facultad de FarmaciaUniversidad de SevillaSevillaSpain

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