Skip to main content
SpringerLink
Log in

The effect of food restriction on kidney membrane structures of aging rats

  • Published:
AGE Aims and scope Submit manuscript

Abstract

Food restriction (FR) was tested for its ability to protect against age-related membrane deterioration of kidney. Mitochondria and microsomes were isolated from male Fischer 344 rats that were either fed ad libitum (AL) or food restricted (60% of ad libitum). The result show the yields of isolated membranes decreased considerably with age in AL fed rats, but much less so in FR rats. Additional information on membrane protection by food restriction came from the analysis of membrane fatty acid composition: the amount of total saturated membrane fatty acid and highly oxidizable arachidonic acid increased in AL rats, and this was effectively modulated by food restriction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yu, B.P., Masoro, E.J., Murata, I., Bertrand, H.A., and Lynd, F.T.: Lifespan study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol., 37: 130–141, 1982.

    PubMed  CAS  Google Scholar 

  2. Masoro, E.J.: Nutrition as a modulator of the aging process. The Physiologist, 27: 98–101, 1983.

    Google Scholar 

  3. Weindruch, R.: Dietary restriction and the aging process, in Free Radicals in Molecular Biology, Aging and Disease, edited by Armstrong, D., Sohal, R.S., Cutler, R.G., and Slater, T.F., New York, Raven Press, 1984, pp. 181–202.

    Google Scholar 

  4. Yu, B.P., Masoro, E.J., and McMahan, C.A.: Nutritional influences on aging of Fischer 344 rats: 1. Physical, metabolic and longevity characteristics. J. Gerontol., 40: 657–670, 1985.

    PubMed  CAS  Google Scholar 

  5. Yu, B.P.: Update on food restriction and aging, in Review of Biological Research in Aging, Vol. III, edited by Rothstein, M., New York, Alan R. Liss, Inc., 1987, pp. 495–505.

    Google Scholar 

  6. Maeda, H., Gleiser, C.A., Masoro, E.J., Murata, I., McMahan, C.A., and Yu, B.P.: Nutritional influences on aging of Fischer 344 rats. II. Pathology. J. Gerontol., 40: 671–688, 1985.

    PubMed  CAS  Google Scholar 

  7. Hayashida, M., Yu, B.P., Masoro, E.J., Iwasaki, K., and Ikeda, T.: An electron microscopic examination of age-related changes in the rat kidney: The influence of diet. Exp. Gerontol., 21: 535–553, 1988.

    Article  Google Scholar 

  8. Everitt, A.V., Porter, B.D., and Wyndham, J.R.: Effects of caloric intake and dietary composition on the development of proteinuria, age-associated renal disease and longevity in the male rat. Gerontology, 28: 168–175, 1982.

    PubMed  CAS  Google Scholar 

  9. Johnson, K.J., Rehan, A., and Ward, P.: The role of oxygen radicals in kidney disease, in Oxygen Radicals and Tissue Injury, edited by Halliwell, B., Bethesda, Fed. Am. Soc. for Exp. Biol., 1988, pp. 115–122.

    Google Scholar 

  10. Harman, D.: Free radical theory of aging: Role of free radicals in origination and evolution of life, aging, and disease processes, in Free Radicals, Aging, and Degenerative Diseases, edited by Johnson, J.E., Jr., Walford, R., Harman, D., and Miguel, I., New York, Alan R. Liss, Inc., 1986, pp. 3–49.

    Google Scholar 

  11. Laganiere, S., and Yu, B.P.: Anti-lipoperoxidation action of food restriction. Biochem. Biophys. Res. Commun., 145: 1185–1191, 1987.

    Article  PubMed  CAS  Google Scholar 

  12. Del Maestro, R.F.: An approach to free radicals in medicine and biology. Acta. Physiol. Scand. Suppl., 492: 43–57, 1980.

    PubMed  Google Scholar 

  13. Mead, J.F.: Free radical mechanisms in lipid peroxidation and prostaglandins, in Free Radicals in Molecular Biology, Aging, and Disease, edited by Armstrong, D., Sohal, R.S., Cutler, R.G., and Slater, T.F., New York, Raven Press, 1984, pp. 53–66.

    Google Scholar 

  14. Tate, E.L., and Herbener, B.H.: A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice. J. Gerontol., 31: 129–134, 1976.

    PubMed  CAS  Google Scholar 

  15. Tauchi, H., and Sato, T.: Changes in hepatic cell mitochondria during parabiosis between old and young rats. Mech. Ageing Dev., 12: 7–14, 1980.

    Article  PubMed  CAS  Google Scholar 

  16. Grinna, L.S.: Changes in cell membranes during aging. Gerontology, 23: 452–464, 1977.

    Article  PubMed  CAS  Google Scholar 

  17. Fleming, J.E., Miguel, J., Cottrell, S.F., Yengoyan, L.S., and Economos, A.C.: Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontology, 28: 44–53, 1982.

    Article  PubMed  CAS  Google Scholar 

  18. Harman, D.: Free radical theory of aging: Consequences of mitochondrial aging. AGE: 86–94, 1983.

  19. Vladimirov, A.Y., Olenev, V.I., Suslova, T.B., and Cheremisina, Z.P.: Lipid peroxidation in mitochondrial membrane, in Advances in Lipid Research, Vol. 17, edited by Paoletti, R., and Kritchevsky, D., New York, Academic Press, 1980, pp. 173–249.

    Google Scholar 

  20. Masoro, E.J., and Yu, B.P:.: Diet and nephropathy. Lab Invest., 60: 165–167, 1989.

    PubMed  CAS  Google Scholar 

  21. Lowry, O.H., Roseborough, N.J., Farr, L.A., and Randall, R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265–275, 1951.

    PubMed  CAS  Google Scholar 

  22. Folch, J., Lees, M., and Sloane Stanley, G.H.: A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497–509, 1957.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, Health Science Center at San Antonio, University of Texas, 7703 Floyd Curl Drive, San Antonio, Texas, 78284-7756

    Jin-Ho Choi & Byung P. Yu

Authors
  1. Jin-Ho Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Byung P. Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Choi, JH., Yu, B.P. The effect of food restriction on kidney membrane structures of aging rats. AGE 12, 133–136 (1989). https://doi.org/10.1007/BF02432350

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02432350

Keywords

Search

Navigation