, Volume 4, Issue 3, pp 85–87 | Cite as

Effect of age and alcohol consumption on plasma lipids in the rat

  • Steven R. Gambert
  • Joseph J. Barboriak


Rats aged 6 weeks (young), 6 months (mature), and 20 months (senescent) were offered alcohol ad libitum for 3 weeks to study the interrelationship between alcohol, age, and serum lipids. Although the total quantity of alcohol consumption increased with age, senescent rats actually consumed less alcohol per gram body weight per day as compared to either mature or young rats. Increasing age alone was associated with higher levels of total serum cholesterol and high-density lipoprotein cholesterol. Triglyceride levels were not affected by age. Alcohol consumption elevated high density lipoprotein cholesterol in young rats, however, did not alter this lipid fraction in either mature or senescent rats. Triglyceride levels were elevated by alcohol only in senescent rats.


Lipid Alcohol Cholesterol Alcohol Consumption High Density Lipoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barboriak, J. and Meade, R.: Postalcoholic lipemia in the rat. Quarterly Journal of Studies on Alcohol, 29: 283–289, 1968.PubMedGoogle Scholar
  2. 2.
    Johansson, B. and Medhus, A.: Increase in plasma α-lipoproteins in chronic alcoholics after acute abuse. Acta. Meal. Scand., 195: 273–277, 1974.Google Scholar
  3. 3.
    Castelli, W., Gordon, T. and Hjortland, M.: Alcohol and blood lipids. Lancet, 2: 153–155, 1977.PubMedCrossRefGoogle Scholar
  4. 4.
    Klatsky, A., Friedman, G. and Siegelaub, A.: Alcohol consumption before myocardial infarction: results from the Kaiser-Permanente epidemiologic study of myocardial infarction. Ann. Intern. Med., 81: 294–301.Google Scholar
  5. 5.
    Statuson, W., Neff, R. and Miettinen, O.: Alcohol consumption and nonfatal myocardial infarction. Am. J. Epidemiol., 104: 603–605, 1976.Google Scholar
  6. 6.
    Henneken, C., Rosner, B. and Cole, D.: Daily alcohol consumption and fatal coronary heart disease. Am. J. Epidemiol., 107: 196–200, 1978.Google Scholar
  7. 7.
    Yano, K., Rhoads, G. and Kagan, A.: Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. N. Engl. J. Med., 297: 405–409, 1977.PubMedCrossRefGoogle Scholar
  8. 8.
    Barboriak, J., Rimm, A. and Anderson, A.: Coronary artery occlusion and alcohol intake. Br. Heart J., 39: 289–293, 1977.PubMedGoogle Scholar
  9. 9.
    Anderson, A., Barboriak, J. and Rimm, A.: Risk factors and angiographically determind coronary occlusion. Am. J. Epidemiol., 107: 8–14, 1978.PubMedGoogle Scholar
  10. 10.
    U.S. Government Printing Office. Lipid Research Clinics Manual of Laboratory Operaions. Vol. 1, 1974.Google Scholar
  11. 11.
    Block, W., Jarrett, J. and Levine, J.: Use of a single color reagent to improve the automated determination of serum total cholesterol, in Automation in Analytical Chemistry, edited by Skeggs, L., Jr., New York, Mediad, 1965, p. 341.Google Scholar
  12. 12.
    Kessler, G. and Lederer, H.: Fluorimetric measurement of triglycerides, in Automation in Analytical Chemistry, edited by Skeggs, L., Jr., New York, Mediad, 1965, p. 341.Google Scholar
  13. 13.
    Barrows, C., Jr. and Roeder, L.: Nutrition, in Handbook of the Biology of Aging, edited by Finch, C. and Hayflick, L., New York. Van Nostrand Reinhold Company, 1977, pp. 561–581.Google Scholar
  14. 14.
    Dupont, J., Mathias, M., Spindler, A. and Janson, P.: Dietary fat saturation and cholesterol turnover in aging rats. Age, 3: 19–23, 1980.Google Scholar
  15. 15.
    Beard, J. and Barboriak, J.: Plasma lipids of dogs during and after chronic ethanol administration. Proc. Soc. Exper. Biol. Med., 118: 1151–1154, 1965.Google Scholar

Copyright information

© American Aging Association, Inc. 1981

Authors and Affiliations

  • Steven R. Gambert
    • 1
    • 2
  • Joseph J. Barboriak
    • 1
    • 2
  1. 1.Department of Medicine and PharmacologyThe Medical College of WisconsinMilwaukee (Wood)
  2. 2.Department of MedicineVeterans Administration Medical CenterMilwaukee (Wood)

Personalised recommendations