Abstract
The effect of propyl gallate (PGL) on life span in Drosophila was investigated. Four groups of flies were supplemented as follows: group 1, no PGL; group 2, no PGL supplement until 28 days followed by 0.3% PGL for remaining life span; group 3, 0.3% PGL from 7 days to 28 days, then none for remaining life span; and group 4, 0.3% PGL from 7 days until death. In all cases, PGL significantly increased mean life span. The largest increase in mean life span (34.2%) was in the group receiving PGL for the entire life span (group 4). Increases of 14.6% and 14.7% were measured in groups 2 and 3, respectively.
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References
Harman, D.: Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 11: 298–300, 1956.
Harman, D.: Role of free radicals in mutation, cancer, aging and the maintenance of life. Rad. Res., 16: 753–763, 1962.
Harman, D.: The biologic clock: The mitochondria? J. Am. Geriatr. Soc., 20: 145–147, 1972.
Harman, D.: The aging process. Proc. Natl. Acad. Sci. USA, 78: 7124–7128, 1981.
Fleming, J.E., Miquel, J., Cottrell, S.F., Yengoyan, L.S., and Economos, A.C.: Is cell aging caused by respiration-dependent injury to the mitochondrial genome? Gerontol. 28: 44–53, 1982.
Harman, D.: Free radical theory of aging: Nutritional implications. Age, 1: 143–150, 1978.
Miquel, J., Fleming, J.E. and Economos, A.C.: Antioxidants, mitochondrial respiration and aging in Drosophila. Arch. Gerontol. Geriatr., 1: 349–363, 1982.
Pearl, R.: The Rate of Living. London: University of London Press, 1928.
Alpatov, W.W. and Pearl, R.: Experimental studies on the duration of life. XII. Influence of temperature during the larval period and adult life on the duration of life of the imago of Drosophila melanogaster. Am. Nat., 63: 37–67, 1929.
Harman, D. Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging, and disease processes, in Free Radicals, Aging, and Degenerative Diseases, edited by Johnson, J.E. Jr., Walford, R., Harman, D. and Miquel, J. New York, Alan R. Liss, 1986, pp. 3–49.
Fridovich, I.: Superoxide and evolution. Horizons in Biochem. Biophys., 1: 1–37, 1974.
Puig-Musset, P.: Oxigeno(s), oikos-tau. Barcelona (Spain): S.A.-Ediciones, 1976.
Gerschman, R.: Biological Effects of Oxygen in the Animal Organism, edited by F. Dickens and E. Nell. New York, McMillan, 1964, pp. 475–492.
Haugaard, N.: Cellular mechanisms of oxygen toxicity. Physiol. Rev., 48: 311–373, 1968.
Menzel, D.: Ann. Rev. Pharmacol., 10: 379–394, 1970.
Pryor, W.A.: Free radical reactions and their importance in biochemical systems. Fed. Proc., 32: 1862–1869, 1973.
Pryor, W.A.: The role of free radical reactions in biological systems, in Free Radicals in Biology, Vol. 1, edited by Pryor, W.A., New York, Academic Press, 1976, pp. 1–49.
Fridovich, I.: The biology of oxygen radicals. Science 201: 875–880, 1978.
Leibovitz, B.E., and Siegel, B.V. Aspects of free radical reactions in biological systems: Aging. J. Gerontol., 35: 45–56, 1980.
Gerschmann, R. The Biological Effects of Increased Oxygen Tension in Man’s Dependence on the Earthly Atmosphere, in Proceedings of the 1958 Int. Symp. on Submarine and Space Medicine, edited by Schaeffer, K.S., New York, McMillan, 1962, pp. 174–179.
Sohal, R.S., Farmer, K.J., Allen, R.G., and Cohen, N.R.: Effect of age on oxygen consumption, superoxide dismutase, catalase, glutathione, inorganic peroxides and chloroform-soluble antioxidants in the adult male housefly, Musca domestica. Mech. Age. Dev., 24: 185–195, 1983.
Massie, H.R., Aiello, V.R., and Williams, T.R. Loss of mitochondrial DNA with aging in Drosophila melanogaster. Gerontologia, 21: 231–238, 1975.
Gehan, E.A. and Siddiqui, M.M.: Simple regression models for survival time studies. J. Am. Stat. Assoc., 344(68): 848–845, 1973.
Thoman, D.R. and Bain, L.J.: Two sample tests in the Weibull distribution. Technometrics, 4(11): 805–815, 1969.
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Ruddle, D.L., Yengoyan, L.S., Miquel, J. et al. Propyl gallate delays senescence in Drosophila melanogaster . AGE 11, 54–58 (1988). https://doi.org/10.1007/BF02431773
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DOI: https://doi.org/10.1007/BF02431773