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AGE

, Volume 5, Issue 1, pp 1–9 | Cite as

Aged rhesus skeletal muscle: Histochemistry and lipofuscin content

  • C. H. Beatty
  • R. M. Bocek
  • P. T. Herrington
  • C. Lamy
  • M. K. Hoskins
Article

Abstract

Sections of sartorius muscle from young adult (6 to 11 yr), adult (15 to 16 yr), and aged (over 20 yr) rhesus monkeys were stained for Ca, Mg-ATPase and succinic dehydrogenase (SDH) activities. Three fiber types-type 1 (slow-twitch oxidative), type 2A (fast-twitch oxidative-glycolytic), and type 2B (fast-twitch glycolytic)-were differentiated. There was a decrease in the percent of type 2B fibers with aging. Some type of morphological pathology was seen in all sartorii from monkeys older than 15 yr, e.g., fiber degeneration and splitting, dedifferentiation, and fiber type grouping. In aged male sartorii the decreases in fiber areas were similar in all three fiber types; in aged female sartorii the areas of types 1 and 2A decreased with no change in the size of type 2B. The number of lipofuscin (LF) granules in aged muscles (monkeys more than 17 yr old) was greater than that in the muscle from young adults (under 10 yr). The increase in LF content with age was about 300% for the soleus and sartorii, and 120% for the predominantly white area of the brachioradialis. In rhesus muscle, as in human muscle, morphological changes with aging appear to be highly variable.

Keywords

Rhesus Monkey Fiber Type Succinic Dehydrogenase Type Grouping Human Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Aging Association, Inc. 1982

Authors and Affiliations

  • C. H. Beatty
    • 1
  • R. M. Bocek
    • 1
  • P. T. Herrington
    • 1
  • C. Lamy
    • 1
  • M. K. Hoskins
    • 1
  1. 1.Perinatal PhysiologyOregon Regional Primate Research CenterBeaverton

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