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Molecular and General Genetics MGG

, Volume 118, Issue 1, pp 45–50 | Cite as

The effect of a histidine operator-constitutive mutation on UV-induced mutability within the histidine operon ofSalmonella typhimurium

  • D. J. Savić
  • D. T. Kanazir
Article

Summary

The presence of the histidine operator-constitutive mutationhis01242 increases UV-induced mutability within the histidine operon ofSalmonella typhimurium. The rate of reversion ofhisC andhisF ochre and frameshift mutants is increased 5- to 8-fold when these mutations are coupled withhis01242 which causes 15-fold derepression of the operon. The effect does not extend to the whole chromosome since the rate of UV-induced mutability at the unlinked streptomycin locus is the same in the strains carryinghis0 + orhis01242 alleles. The same phenomenon was observed in Hcr strains.

Keywords

Reversion Frequency Nutrient Agar Plate Lactose Operon Histidinol Elevated Transcription 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • D. J. Savić
    • 1
    • 2
  • D. T. Kanazir
    • 1
    • 2
  1. 1.Laboratory for BiochemistryInstitute for Nuclear Sciences “Boris Kidrič”, VinčaBeogradYugoslavia
  2. 2.Department for Molecular Biology, Faculty of SciencesUniversity of BeogradYugoslavia

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