Summary
Islet cell antibodies were investigated in 127 non-diabetic children after mumps infection and in four out of seven children who developed diabetes mellitus shortly after active mumps vaccination. Twenty-one of the children who had mumps and all four vaccinated children who were tested had islet cell cytoplasmic antibodies. In contrast, islet cell surface antibodies were detected in 43 out of 68 patients with mumps infection and in 32 out of 44 patients with other viral diseases. All but one mumps-infected child and all the other viral infected patients investigated did not develop diabetes mellitus. The mumps-infected ICA positive children did not show those HLA-frequencies associated with Type 1 diabetes.
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References
Harris HF (1899) A case of diabetes mellitus quickly following mumps. Boston Med Surg J 140: 465–469
McCrae WM (1963) Diabetes mellitus following mumps. Lancet 1:1300–1301
Peig M, Ercilla G, Milian M, Gomis R (1981) Post-mumps diabetes mellitus. Lancet 1:1007 (Letter)
Toniolo A, Onodera T (1979) Viruses and diabetes. In: Andreani D, Federlin K, DiMario O, Heding LG (eds) Immunology in diabetes. Kimpton Medical Publications, London, pp 71–93
Helmke K, Otten A, Willems W (1980) Islet cell antibodies in children with mumps-infection. Lancet 2: 211–212 (Letter)
Bottazzo GF, Dean BM, Gorsuch AN, Cudworth AG, Doniach D (1980) Complement-fixing islet cell antibodies in Type I diabetes: Possible monitors of active beta-cell damage. Lancet 1: 668–672
Lernmark A, Reedmann ZR, Hofmann C, Rubinstein AH, Steiner DF, Jackson RL, Winter RJ, Traisman HS (1978) Islet cell surface antibodies in juvenile diabetes mellitus. New Engl J Med 299: 375–380
Terasaki PI, McClelland JD (1964) Microdroplet assay human serum cytotoxins. Nature 204: 998–1000
Mueller-Eckhardt G, Stief T, Otten A, Helmke K, Willems WR, Mueller-Eckhardt C (1984) Complications of mumps infection, islet cell antibodies and HLA. Immunobiol 167: 338–344
Sinaniotis CA, Daskalopoulon E, Lapatsanis P, Doxiadis S (1975) Diabetes mellitus after mumps vaccination. Arch Dis Childhood 50: 749–750 (Letter)
Menser MA, Forrest JM, Bransby RD (1978) Rubella infection and diabetes mellitus. Lancet 1: 57–60
Gamble DR (1980) Relation of antecedent illness to development of diabetes in children. Br Med 1281: 99–101
Ratzmann KP, Streu J, Witt S, Berling H, Keilacker H, Michaelis D (1984) Mumps infection and insulin-dependent diabetes mellitus (IDDM). Diabetes Care 7:170–173
Rayfield EJ, Seto Y (1978) Viruses and the pathogenesis of diabetes mellitus. Diabetes 27:1126–1139
Pyke DA (1979) The genetic connections. Diabetologia 17: 333–343
Richens ER, Jones WG (1981) Islet cell antibodies and mumps. Lancet 1: 507–508 (Letter)
Bruining G, Molenaar JJ, Tuk CW, Lindemann J, Bruining HA, Maerner B (1984) Clinical time-course and characteristics of islet cell cytoplasmatic antibodies in childhood diabetes. Diabetologia 26:24–29
Gleichmann H, Zörcher B, Greulich B, Gries FA, Henrichs HR, Bertrams J, Kolb H (1984) Correlation of islet cell antibodies and HLA-DR phenotypes with diabetes mellitus in adult. Diabetologia 27: 90–92
Örvell C (1984) The reactions of monoclonal antibodies with structural proteins of mumps virus. J Immunol 132: 2622–2629
Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. New Engl J Med 300: 1173–1179
Champasur HF, Bottazzo GF (1982) Virologic immunologic and genetic factors in insulin-dependent diabetes mellitus. J Pediatrics 100:15–20
Gorsuch AN, Spencer KM, Lister J, McNally JM, Dean BM, Bottazzo GF, Cudworth AG (1981) Evidence for a long pre-diabetic period in Type 1 (insulin-dependent) diabetes mellitus. Lancet 2: 1363–1365
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Helmke, K., Otten, A., Willems, W.R. et al. Islet cell antibodies and the development of diabetes mellitus in relation to mumps infection and mumps vaccination. Diabetologia 29, 30–33 (1986). https://doi.org/10.1007/BF02427277
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DOI: https://doi.org/10.1007/BF02427277